M Mirowski 1 , R Wierzbicki
1. Zakład Biochemii Instytutu Badania Srodowiska i Bioanalizy Akademii Medycznej,Lodzi.
Published:
GICID: 01.3001.0000.2806
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1993; 47 (2)
Abstract
The article contains a survey of the recent papers on the fibrinolytic inhibitors which regulate the process of plasminogen activation–PAI-1 and PAI-2. Both of them belong to serine protease inhibitors family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1:1 with them. PAI-1, secreted mainly by endothelial cells and platelets, is the main plasmic inhibitor of plasminogen activation. PAI-2, originated essentially from placenta, appears in blood during pregnancy.