T H Zastawny 1 , R Oliński
1. Zakład Biochemii Klinicznej Akademii Medycznej, Bydgoszczy.
Published:
GICID: 01.3001.0000.2803
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1993; 47 (2)
Abstract
Cis-DDP is an antitumor drug with activity against various human tumors. It is generally accepted that DNA is the cellular target of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eukaryotic systems. We also discuss the possible mechanisms of acquired resistance of cancerous cells to cis-DDP and analogues, and potential clinical implication of this phenomenon.