P Kuśnierczyk 1
1. Laboratorium Immunogenetyki Zakładu Immunologii Klinicznej.
Published:
GICID: 01.3001.0000.3014
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1995; 49 (1)
Abstract
Human major histocompatibility complex class I molecules, HLA-A and -B, bind peptides derived from intracellular proteins, transport them to the cell surface and present them to T lymphocytes. Much less is known about the function of the third “classical” class I molecule, HLA-C. Recent data disclosing remarkable polymorphism of HLA-C, possible importance of this molecule for the recognition of target cells by nature killer cells, and capability to present viral antigens to the T lymphocytes are reviewed. Preliminary results from our laboratory on binding of synthesis peptides to HLA-Cw3+ cells are presented.