D Piskorska 1 , R Grabowska-Bochenek
1. Katedra i Zakład Biochemii i Chemii Slaaskiej Akademii Medycznej w Katowicach.
Published:
GICID: 01.3001.0000.3045
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1995; 49 (3)
Abstract
The glyoxalase system catalyses the conversion of methylglyoxal (and other 2-ketoaldehydes) to D-lactic acid via the intermediate S-D-lactoylglutathione. It comprises two enzymes, glyoxalases I and glyoxalases II, and catalytic amount to reduced glutathione. Methylglyoxal inhibits cell growth, while the glyoxalase system by breaking down methylglyoxal may act as a promoter of cell growth. Inhibitors of glyoxalases may serve as possible therapeutic agents against cancer by virtue of their ability to elevate the level of methylglyoxal in the body.