[Signaling pathways and their role in maturation and function of T lymphocytes]

J Matuszyk ¹ , L Strzadała

1. Laboratorium Immunologii Komórkowej Instytutu Immunologii i Terapii DoświadczalnejPAN im. L. Hirszfelda we Wrocławiu.

Published:

GICID: 01.3001.0000.3138

Available language versions: en pl

Issue: Postepy Hig Med Dosw 1997; 51 (4)

Abstract

Signals delivered through the beta/gp33 (pre-TCR) and T-cell receptor alpha beta control proliferation and differentiation of thymocytes at two distinct control points of T cell maturation. Interaction between T-cell receptor (TCR) and peptide/MHC complex induce signaling pathways leading to activation of T cell. Signal transduction involves CD3 zeta phosphorylation by Lck tyrosine kinase and activation of ZAP-70 which regulates signaling pathways through PKC, Ca++ and Ras/Raf kinase cascade. Appropriate response of cell is preceded by integration of different signals in the nucleus.