[Disturbance of the normal cell cycle by T antigens of SV40 viruses and JC cause some tumors]

B Kryńska ¹ , J Lewin-Kowalik , A L Sieroń

1. Center for NeuroVirology and NeuroOncology, Allegheny University of the HealthSciences, Philadelphia, USA.

Published:

GICID: 01.3001.0000.3173

Available language versions: en pl

Issue: Postepy Hig Med Dosw 1998; 52 (3)

Abstract

The mechanism that may lead to tumor formation in SV40 or JCV infected tissues based on previously reported interactions between T antigens and two factors (p53 and pRb) controlling cell cycle has been discussed. p53 is a known tumor suppressor protein that delays S phase entry causing cell arrest in G1 phase or apoptosis when the DNA damage occurs. Phosphorylation of pRB releases E2F family proteins that activate genes encoding S phase promoting factors. Binding of T antigens to pRB induces tumor formation, whereas tumor proliferation requires knockout of p53 activity.