COMMENTARY ON THE LAW
[Induction of apoptosis by receptors for factors from the TNF family]
T Grzela 1 , M Ołdak , J Jóźwiak , J Malejczyk
1. Pracownia Biologii Molekularnej Komórki Zakładu Histologii i Embriologii Instytutu,Biostruktury Akademii Medycznej w Warszawie.
Published:
GICID: 01.3001.0000.3224
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1999; 53 (2)
Abstract
Mechanisms leading to induction of apoptosis by TNF family receptors involve intracellular activation of cysteinyl-aspartate-specific proteases (caspases). Caspase activation requires engagement of adaptor proteins. It is plausible, that caspase activation is sufficient for cell death in course of receptor-dependent induction of apoptosis. However, there are some data that programmed cell death involves also generation of ceramides, arachidonic acid metabolism, or MAP kinase (SAPK/JNK) activation. On the other hand, TNF receptor family triggers some protective, anti-apoptotic mechanisms, i.e. protein kinase C (PKC) and NF-kappa B. The outcome of induction of apoptosis by TNF receptor family depends on the cell type, its physiological condition and influence of environmental factors.