L Strzadała 1
1. Laboratorium Immunologii Komórkowej, Instytutu Immunologii i Terapii DoświadczalnejPAN, Wrocławiu.
Published:
GICID: 01.3001.0000.3223
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1999; 53 (2)
Abstract
The abrogation of apoptosis during development of thymocytes could contribute to the lymphomagenesis of immature thymocytes which otherwise would be deleted. In agreement with this possibility it was found that cells of thymic lymphomas from TCR anty H-Y transgenic mice were resistant to TCR mediated apoptosis. Molecular mechanism responsible for resistance to TCR/Nur77-mediated apoptosis in these lymphomas is discussed.