[The role of MAP kinases and inducible transcription factors in the regulation of cell death and survival]

B Kamińska ¹ , B Pyrzyńska

1. Pracownia Regulacji Transkrypcji Zakładu Biochemii Komórki, Instytutu BiologiiDoświadczalnej PAN, Warszawie.

Published:

GICID: 01.3001.0000.3218

Available language versions: en pl

Issue: Postepy Hig Med Dosw 1999; 53 (2)

Abstract

Cell growth and survival are constantly promoted and modulated by a variety of extracellular stimuli. Modules of sequentially activating protein kinases serve as important routes for the intracellular transmission of signals from diverse stimuli to nucleus. The Raf signaling involving Mitogen-Activated Protein (MAP) kinases is a key element of mitogenic stimulation. The c-Jun N-terminal kinases (JNKs) are activated in cells in response to cytokines, stress or proapoptotic stimuli, indicating that this signaling pathway may contribute to inflammatory and cell death phenomena. Cross-talk between different MAP kinase signaling pathways determines cellular responses in stress, apoptosis and normal physiological processes.