Chemical modifications of macromolecules and their use in the preparation of protein antitumor drug conjugates, vaccines and diagnostic reagent

Janusz Boratyński

Published: 2000-01-15

GICID: 01.3001.0000.3260

Available language versions: en

Issue: Postepy Hig Med Dosw 2000; 54 (1)

Abstract

This article reviews high temperature glycation of proteins, and describes some applications of thus recived neoglycoconjugates as vaccines or drug and gene carriers. The use of macromolecules: antibodies, fibrinogen and natural or synthetic polymers as antitumor drug carriers is discussed. Moreover the article presents method for monitoring of proteins modification by glutaraldehyde.