REVIEW ARTICLE

Molecular mechanisms regulating transport of low molecular substances in hapatocyte

Krzysztof Zwierz , Przemysław Wielgat , Małgorzata Borzym-Kluczyk

Published: 2003-01-15

GICID: 01.3001.0000.3529

Available language versions: en

Issue: Postepy Hig Med Dosw 2003; 57 (1)

Abstract

Transporters of sinusoidal and lateral membranes mediate uptake of inorganic and organic substances to hepatocyte. In hepatocyte lipophilic compounds are biotransformed (hydroxylated and conjugated) and excreted into bile and urine. Vectorial movement of solutes and water from blood to bile is maintained by pumps of ABC superfamily secreting bile salts (bile acid dependent flow) and other solutes: bilirubin, phospholipids, glutathione and inorganic salts (bile acid independent flow).