COMMENTARY ON THE LAW

Regulation of NF-kB activity

Jakub Siednienko , Wojciech Gorczyca

Published: 2003-01-15

GICID: 01.3001.0000.3525

Available language versions: en

Issue: Postepy Hig Med Dosw 2003; 57 (1)

Abstract

Nuclear factor kB (NF-kB) is common proinflammatory transcription factor involved in expression of c.a. 300 different genes. It is usually present in the cytosol as an inactive complex and upon activation translocates into the nucleus. The mechanisms of activation of NF-kB are complex and they involve several different signaling pathways and plethora of proteins. In this minireview we describe the main deciphered as well as suggested mechanisms regulating of NF-kB activity.