COMMENTARY ON THE LAW
Oxazaphosphorinane drugs. New analogues, metabolic studies, and therapeutic approaches
Konrad Misiura 1
1. Zakład Chemii Bioorganicznej, Centrum Badań Molekularnych i Makromolekularnych PAN, Łódź
Published: 2004-12-07
GICID: 01.3001.0000.3621
Available language versions: en pl
Issue: Postepy Hig Med Dosw 2004; 58 (0)
Abstract
Recent studies on oxazaphosphorinane drugs, with the main focus on those carried out in Poland, are briefly reviewed. Research leading to the introduction of the new antitumor drug (S)-(–)-bromofosfamide are presented. The utility of phosphorus nuclear magnetic resonance in studies of ifosfamide metabolism and an application of analogues of the final, active metabolite of this drug in gene therapy are shown