Abstract

We have reviewed recent publications regarding the microbiological characteristic and pathogenicity of a novel infectious agent, the mineral-forming, sterile-filterable, slow-growing Gram-negative Nanobacteria, detected in bovine/human blood, kidney cyst fluid, urine and kidney stones. According to their 16S rDNA structure, nanobacteria belong to the alpha-2 Proteobacteria, subgroup, which includes the Brucella and Bartonella species. Their cell diameter is 0.2-0.5 microm (the smallest known cell-walled bacteria). Their most remarkable characteristic is the formation of carbonate apatite crystals of neutral pH and at physiologic phosphate and calcium concentrations. The extracellular mineralization forms a hard protective shelter for these hardy microorganisms, and enables them to survive conditions of physical stress that would be lethal to most other bacterial species. The Olavi Kajander group (Finland) suggests that the apatite produced by nanobacteria may play a key role in the formation of all kidney stones, by providing a central calcium phosphate deposit around which other crystalline components can collect. Nanobacteria seems to be a causative agent of diseases related to biomineralization processes.

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