Abstract

Civilization development is associated with immense progress in science and significant improvement of human living conditions but simultaneously it contributes to many health problems including metabolic syndrome. Metabolic syndrome is a set of mutually associated factors including insulin resistance, hyperinsulinemia, obesity, lipids disorders and hypertension, which is the main cause of development of coronary heart disease and type 2 diabetes. The first line of defense against metabolic syndrome is a change of life style including body mass reduction, application of a low-calorie diet and performance of physical activity. In spite of the simplicity of therapy, long-term success of the above treatment among patients is observed seldom because it is very difficult to obey rigorous rules. Nowadays, it is considered that diet supplements including antioxidants, polyunsaturated fatty acids and mineral elements are helpful in metabolic syndrome treatment due to their antioxidant and anti-inflammatory properties. It is considered that a health balanced diet enriched with various diet supplements may be the best strategy in metabolic syndrome treatment.

References

• 1. Abete I., Goyenechea E., Zulet M.A., Martinez J.A.: Obesity andmetabolic syndrome: potential benefit from specific nutritionalcomponents. Nutr. Metab. Cardiovasc. Dis., 2011; 21, Suppl. 2: B1-B15
  Google Scholar
• 2. Andersen G., Burkon A., Sulzmaier F.J., Walker J.M., Leckband G.,Fuhst R., Erbersdobler H.F., Somoza V.: High dose of dietary resveratrolenhances insulin sensitivity in healthy rats but does not leadto metabolite concentrations effective for SIRT1 expression. Mol.Nutr. Food Res., 2011; 55: 1197-1206
  Google Scholar
• 3. Arumugam S., Thandavarayan R.A., Veeraveedu P.T., Ma M., GiridharanV.V., Arozal W., Sari F.R., Sukumaran V., Lakshmanan A.,Soetikno V., Suzuki K., Kodama M., Watanabe K.: Modulation of endoplasmicreticulum stress and cardiomyocyte apoptosis by mulberryleaf diet in experimental autoimmune myocarditis rats. J. Clin.Biochem. Nutr., 2012; 50: 139-144
  Google Scholar
• 4. Asdaq S.M., Inamdar M.N.: Potential of garlic and its active constituent,S-allyl cysteine, as antihypertensive and cardioprotectivein presence of captopril. Phytomedicine, 2010; 17: 1016-1026
  Google Scholar
• 5. Banz W.J., Iqbal M.J., Bollaert M., Chickris N., James B., HigginbothamD.A., Peterson R., Murphy L.: Ginseng modifies the diabeticphenotype and genes associated with diabetes in the male ZDF rat.Phytomedicine, 2007; 14: 681-689
  Google Scholar
• 6. Basu A., Betts N.M., Mulugeta A., Tong C., Newman E., LyonsT.J.:Green tea supplementation increases glutathione and plasma antioxidantcapacity in adults with the metabolic syndrome. Nutr.Res., 2013; 33: 180-187
  Google Scholar
• 7. Basu A., Sanchez K., Leyva M., Wu M., Betts N., Aston C., LyonsT.: Green tea supplementation affects body weight, lipids, and lipidperoxidation in obese subjects with metabolic syndrome. J. Am. Coll.Nutr., 2010; 29: 31-40
  Google Scholar
• 8. Bogdanski P., Suliburska J., Szulinska M., Stepien M., Pupek-MusialikD., Jablecka A.: Green tea extract reduces blood pressure, inflammatorybiomarkers, and oxidative stress and improves parametersassociated with insulin resistance in obese, hypertensivepatients. Nutr. Res., 2012; 32: 421-427
  Google Scholar
• 9. Brasnyo P., Molnar G.A., Mohas M., Marko L., Laczy B., Cseh J.,Mikolas E., Szijarto I.A., Merei A., Halmai R,. Meszaros L.G., SumegiB., Wittmann I.: Resveratrol improves insulin sensitivity, reducesoxidative stress andactivates the Akt pathway in type 2 diabeticpatients. Br. J. Nutr., 2011; 106: 383-389
  Google Scholar
• 10. Broncel M., Koziróg M., Duchnowicz P., Koter-Michalak M., SikoraJ., Chojnowska-Jezierska J.: Aronia melanocarpa extract reducesblond pressure, serum endothelin, lipid, and oxidative stress markerlevels in patients with metabolic syndrome. Med. Sci. Monit.,2010; 16: CR28-CR34
  Google Scholar
• 11. Broncel M., Koziróg-Kołacińska M., Andryskowski G., DuchnowiczP., Koter-Michalak M., Owczarczyk A., Chojnowska-Jezierska J.:Wpływ antocyjanin z aronii czarno owocowej na ciśnienie tętniczeoraz stężenie endoteliny-1 i lipidów u pacjentów z zespołem metabolicznym.Pol. Merk. Lek., 2007; 23: 116-119
  Google Scholar
• 12. Cituk M., Jeznach-Steinhagen A., Sińska B.: Zespół metaboliczny– zmiany w kryteriach rozpoznawania. Przew. Lek., 2007; 6: 558-562
  Google Scholar
• 13. Di Renzo L., Galvano F., Orlandi C., Bianchi A., Di Giacomo C.,La Fauci L., Acquaviva R., De Lorenzo A.: Oxidative stress in normal–weight obese syndrome. Obesity, 2010; 18: 2125-2130
  Google Scholar
• 14. Drzycimska-Tatka B., Drab-Rybczyńska A., Kasprzak J.: Zespół metaboliczny– epidemia XXI wieku. Hygeia Public Health, 2011; 46: 423-430
  Google Scholar
• 15. Duchnowicz P., Nowicka A., Koter-Michalak M., Broncel M.: Invivo influence of extract from Aronia melanocarpa on the erythrocytemembranes in patients with hypercholesterolemia. Med. Sci.Monit., 2012; 18: CR569-CR574
  Google Scholar
• 16. Filho P.R., Castro I., Stahlschmidt A.: Effect of red wine associatedwith physical exercise in the cardiovascular system of spontaneouslyhipertensive rats. Arq. Bras. Cardiol, 2011; 96: 277-283
  Google Scholar
• 17. Fumeron F., Lamri A., Abi Khalil C., Jaziri R., Porchay-BaldérelliI., Lantieri O., Vol S., Balkau B., Marre M.: Dairy consumption andthe incidence of hyperglycemia and the metabolic syndrome: resultsfrom a french prospective study, data from the EpidemiologicalStudy on the Insulin Resistance Syndrome (DESIR). DiabetesCare, 2011; 34: 813-817
  Google Scholar
• 18. Gad M.A., Abd El-Twab S.M.: Selenium toxicosis assessment (invivo and in vitro) and the protective role of vitamin B12 in male quail(Coturnix coturnix). Environ. Toxicol. Pharmacol., 2009; 27: 7-16
  Google Scholar
• 19. Gertig H.: Suplementy diety – czas na zmiany. Nowiny Lekarskie,2008; 77: 236-238
  Google Scholar
• 20. Gómez-Arbeláez D., Lahera V., Oubiña P., Valero-Muñoz M., HerasN., Rodríguez Y., García R., Camacho P.A., López-Jaramillo P.: Agedgarlic extract improves adiponectin levels in subjects with metabolicsyndrome: a double-blind, placebo-controlled, randomized, crossoverstudy. Mediators Inflamm., 2013; 2013: 285795
  Google Scholar
• 21. Guerrera M., Volpe S., Mao J.: Therapeutic uses of magnesium.Am. Fam. Physician, 2009; 80: 157-162
  Google Scholar
• 22. Ihm S.H., Jang S.W., Kim O.R., Chang K., Oak M.H., Lee J.O., LimD.Y., Kim J.H.: Decaffeinated green tea extract improves hypertensionand insulin resistance in a rat model of metabolic syndrome.Atherosclerosis, 2012; 224: 377-383
  Google Scholar
• 23. Jung M.H., Seong P. N., Kim M.H., Myong N.H., Chang M.J.: Effectof green tea extract microencapsulation on hypertriglyceridemiaand cardiovascular tissues in high fructose-fed rats. Nutr. Res.Pract., 2013; 7: 366-372
  Google Scholar
• 24. Jurgoński A., Juśkiewicz J., Zduńczyk Z.: Ingestion of black chokeberryfruit extract leads to intestinal and systemic changes ina rat model of prediabetes and hyperlipidemia. Plant Foods Hum.Nutr., 2008; 63: 176-182
  Google Scholar
• 25. Kassi E., Pervanidou P., Kaltsas G., Chrousos G.: Metabolic syndrome:definitions and controversies. BMC Med., 2011; 5: 481-413
  Google Scholar
• 26. Khatua T.N., Padiya R., Karnewar S., Kuncha M., Agawane S.B.,Kotamraju S., Banerjee S.K.: Garlic provides protection to mice heartagainst isoproterenol-induced oxidative damage: role of nitricoxide. Nitric Oxide, 2012; 27: 9-17
  Google Scholar
• 27. Kim H.G., Yoo S.R., Park H.J., Lee N.H., Shin J.W., Sathyanath R.,Cho J.H., Son C.G.: Antioxidant effects of Panax ginseng C.A. Meyerin healthy subjects: a randomized, placebo-controlled clinical trial.Food Chem. Toxicol., 2011; 49: 2229-2235
  Google Scholar
• 28. Kojima Y., Kimura T., Nakagawa K., Asai A., Hasumi K., OikawaS., Miyazawa T.: Effects of mulberry leaf extract rich in 1-deoxynojirimycinon blood lipid profiles in humans. J. Clin. Biochem. Nutr.,2010; 47: 155-161
  Google Scholar
• 29. Kowalczyk E., Fijałkowski P., Kura M., Krzesiński P., Błaszczyk J.,Kowalski J., Smigielski J., Rutkowski M., Kopff M.: The influence ofanthocyanins from Aronia melanocarpa on selected parameters ofoxidative stress and microelements contents in men with hypercholesterolemia.Pol. Merkur. Lekarski, 2005; 113: 651-653
  Google Scholar
• 30. Lim S., Yoon J.W., Choi S.H., Cho B.J., Kim J.T., Chang H.S., ParkH.S., Park K.S., Lee H.K., Kim Y.B., Jang H.C.: Effect of ginsam, a vinegarextract from Panax ginseng, on body weightand glucose homeostasisin an obese insulin-resistant rat model. Metabolism, 2009; 58: 8-15
  Google Scholar
• 31. Mansego M.L., Redon J., Martinez-Hervas S., Real J.T., MartinezF., Blesa S., Gonzalez-Albert V., Saez G.T., Carmena R., Chaves F.J.:Different impacts of cardiovascular risk factors on oxidative stress.Int. J. Mol. Sci., 2011; 12: 6146-6163
  Google Scholar
• 32. Marchesi C., Ebrahimian T., Angulo O., Paradis P., Schiffrin E.:Endothelial nitric oxide synthase uncoupling and perivascular adiposeoxidative stress and inflammation contribute to vascular dysfunctionin a rodent model of metabolic syndrome. Hypertension,2009; 54: 1384-1392
  Google Scholar
• 33. Olas B., Wachowicz B., Nowak P., Kedzierska M., Tomczak A.,Stochmal A., Oleszek W., Jeziorski A., Piekarski J.: Studies on antioxidantproperties of polyphenol-rich extract from berries of Aroniamelanocarpa in blood platelets. J. Physiol. Pharmacol., 2008;59: 823-835
  Google Scholar
• 34. Pacholczyk M., Ferenc T., Kowalski J.: Zespół metaboliczny. CzęśćI: Definicje i kryteria rozpoznawania zespołu metabolicznego. Epidemiologiaoraz związek z ryzykiem chorób sercowo-naczyniowychi cukrzycy typu 2. Postępy Hig. Med. Dośw., 2008; 62: 530-542
  Google Scholar
• 35. Pacholczyk M., Ferenc T., Kowalski J.: Zespół metaboliczny. CzęśćII: patogeneza zespołu metabolicznego i jego powikłań. Postępy Hig.Med. Dośw., 2008; 62: 543-558
  Google Scholar
• 36. Padiya R., Khatua T.N., Bagul P.K., Kuncha M., Banerjee S.K.: Garlicimproves insulin sensitivity and associated metabolic syndromesin fructose fed rats. Nutr. Metab., 2011; 8: 53
  Google Scholar
• 37. Palchaudhuri S., Raymond A., Carlson E.A., Li Y., Zelikoff J.T.:Cytotoxic and cytoprotective effects of selenium of bluegill sunfish(Lepomis macrochirus) phagocytic cells in vitro. Bull. Environ. Contam.Toxicol., 2001; 67: 672-679
  Google Scholar
• 38. Partida-Hernández G., Arreola F., Fenton B., Cabeza M., Román–Ramos R., Revilla-Monsalve M.: Effect of zinc replacement on lipidsand piloproteins in type 2-diabetic patiens. Biomed. Pharmacother.,2006; 60: 161-168
  Google Scholar
• 39. Pawłowska J., Witkowski J., Bryl E.: Zespół metaboliczny – aktualnystan wiedzy o przyczynach i patomechanizmach. Forum Med.Rodzinnej, 2009; 4: 278-291
  Google Scholar
• 40. Poudyal H., Panchal S.K., Diwan V., Brown L.: Omega-3 fattyacids and metabolic syndrome: effects and emerging mechanismsof action. Prog. Lipid Res., 2011; 50: 372-387
  Google Scholar
• 41. Rabe K., Lehrke M., Parhofer K.G., Broedl U.C: Adipokines andinsulin resistance. Mol. Med., 2008; 14: 741-751
  Google Scholar
• 42. Ried K., Frank O.R., Stocks N.P., Fakler P., Sullivan T.: Effect ofgarlic on blood pressure: a systematic review and meta-analysis.BMC Cardiovasc. Disord., 2008; 13: 1-12
  Google Scholar
• 43. Robich M.P., Osipov R.M., Chu L.M., Han Y., Feng J., Nezafat R.,Clements R.T., Manning W.J., Sellke F.W.: Resveratrol modifies riskfactors for coronary artery disease in swine with metabolic syndromeand myocardial ischemia. Eur. J. Pharmacol., 2011; 664: 45-53
  Google Scholar
• 44. Romieu I., Garcia-Esteban R., Sunyer J., Rios C., Alcaraz-ZubeldiaM., Velasco S., Holguin F.: The effect of supplementation withomega-3 polyunsaturated fatty acids on markers of oxidative stressin elderly exposed to PM2.5. Environ. Health Perspect., 2008; 116:1237-1242
  Google Scholar
• 45. Ryszawa N., Kawczyńska-Dróżdż A., Pryjma J., Czesnikiewicz–Guzik M., Adamek-Guzik T., Naruszewicz M., Korbut R., Guzik T.J.:Effects of novel plant antioxidants on platelet superoxide productionand aggregation in arteriosclerosis. J. Physiol. Pharmacol., 2006;57: 611-626
  Google Scholar
• 46. Sener A., Zhang Y., Bulur N., Louchami K., Malaisse W., CarpentierY.: The metabolic syndrome of ω3-depleted rats. II. Bodyweight, adipose tissue mass and glycemic homeostasis. Int. J. Mol.Med., 2009; 24: 125-129
  Google Scholar
• 47. Spallholz J.E., Palace V.P., Reid T.W.: Methioninase and selenomethioninebut not Se-methylselenocysteine generates methylselenoland superoxide in an in vitro chemiluminescent assay: implicationsfor the nutritional carcinostatic activity of selenoamino acids. Biochem.Pharmacol., 2004; 67: 547-554
  Google Scholar
• 48. Stancliffe R., Thorpe T., Zemel M.: Dairy attentuates oxidativeand inflammatory stress in metabolic syndrome. Am. J. Clin. Nutr.,2011; 94: 422-430
  Google Scholar
• 49. Stern M.P., Williams K., González-Villalpando C., Hunt K.J., HaffnerS.M.: Does the metabolic syndrome improve identification ofindividuals at risk of type 2 diabetes and/or cardiovascular disease?Diabetes Care, 2004; 27: 2676-2681
  Google Scholar
• 50. Sugimoto M., Arai H., Tamura Y., Murayama T., Khaengkhan P.,Nishio T., Ono K., Ariyasu H., Akamizu T., Ueda Y., Kita T., Harada S.,Kamei K., Yokode M.: Mulberry leaf ameliorates the expression profileof adipocytokines by inhibiting oxidative stress in white adiposetissue in db/db mice. Atherosclerosis, 2009; 204: 388-394
  Google Scholar
• 51. Tayyebi-Khosroshahi H., Houshyar J., Tabrizi A., Vatankhah A.,Razzagi Zonouz N., Dehghan-Hesari R.: Effect of omega-3 fatty acidon oxidative stress in patients on hemodialysis. Iran. J. Kidney. Dis.,2010; 4: 322-326
  Google Scholar
• 52. Wang Z., Nakayama T.: Inflammation, a link between obesityand cardiovascular disease. Mediators Infamm., 2010; 2010: 535918
  Google Scholar
• 53. Xie J.T., Wang C.Z., Ni. M., Wu J.A., Mehendale S.R., Aung H.H.,Foo A., Yuan C.S.: American ginseng berry juice intake reduces bloodglucose and body weight in ob/ob mice. J. Food Sci., 2007; 72: 590-594
  Google Scholar
• 54. Yang Y., Chan S.W., Hu M., Walden R., Tomlinson B.: Effects ofsome common food constituents on cardiovascular disease. ISRNCardiology, 2011; 2011: 397136
  Google Scholar
• 55. Yin J., Zhang H., Ye J.: Traditional Chinese medicine in treatmentof metabolic syndrome. Endocr. Metab. Immune Disord. DrugTargets, 2008; 8: 99-111
  Google Scholar
• 56. Ziobro A., Sicińska P., Koter-Michalak M.: Stres oksydacyjnyw zespole metabolicznym a suplementacja wyciągiem z Aronia melanocarpa.Problemy Terapii Monitorowanej, 2011; 22: 135-145
  Google Scholar
• 57. Zulet M., Puchau B., Hermsdorff H., Navarro C., Martínez J.: Dietaryselenium intake is negatively associated with serum sialic acidand metabolic syndrome features in healthy young adults. Nutr.Res., 2009; 29: 41-48
  Google Scholar

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