Hen’s egg as a source of valuable biologically active substances

COMMENTARY ON THE LAW

Hen’s egg as a source of valuable biologically active substances

Zygmunt Zdrojewicz 1 , Marta Herman 2 , Ewa Starostecka 2

1. Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski Kształcenia Podyplomowego, Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami
2. Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

Published: 2016-07-06
DOI: 10.5604/17322693.1208892
GICID: 01.3001.0009.6853
Available language versions: en pl
Issue: Postepy Hig Med Dosw 2016; 70 : 751-759

 

Abstract

The aim of this article is to show current knowledge concerning valuable substances biologically active present in hen eggs and underline important nutritive role of hen eggs. Hen egg is a good source of nutrients such as proteins, vitamins (A, B2, B6, B12, D, E, K), minerals and lipids. The significant part of lipids is a group of unsaturated phospholipids, which are components of cell membranes, act protectively on the cardiovascular system and contribute to a decrease of cholesterol level and blood pressure. Therefore, the consumption of unsaturated phospholipids is recommended especially in patients suffering from diseases of the cardiovascular system. Another important substance is egg cystatin, which has a wide spectrum of biological functions, for example the ability to stimulate cell growth, inhibit inflammatory processes and has antibacterial and antiviral properties. Other substance presented in the egg white which helps fight bacteria is lysozyme. It is used in medicine as an aid in antibiotic therapy and analgesic in the course of infection, as well as in tumor malignancies. Among the components contained in the egg yolk there is also immunoglobulin Y which due to its therapeutic importance deserves special attention. Its use offers the possibility of replacing chemotherapeutic agents in the treatment of bacterial infections of digestive system, as well as an opportunity for the development of medicine associated with passive immunization of patients. The egg is a rich source of retinol which gradual depletion in the organism causes many eye pathologies. A very important and useful part of the egg, used in medicine is a shell and its membranes, due to the high collagen content relevant in the treatment of connective tissue diseases.

References

  • 1. Abdou A.M., Kim M., Sato K.: Functional proteins and peptides ofhen’s egg origin, bioactive food peptides in health and disease. In. Tech.,2013: 115-144
    Google Scholar
  • 2. Beaton G.H.: Effectiveness of vitamin A supplementation in the controlof young child morbidity and mortality in developing countriesNew York, United Nations Administrative Committee on Coordination/Subcommittee on Nutrition, 1993; ACC/SCN State-of-the-art Series,Nutrition Policy Discussion Paper No 1
    Google Scholar
  • 3. Carrette O., Demalte I., Scherl A., Yalkinoglu O., Corthals G., BurkhardP., Hochstrasser D.F., Sanchez J.C.: A panel of cerebrospinal fluidpotential biomarkers for the diagnosis of Alzheimer’s disease. Proteomics,2003; 3: 1486-1494
    Google Scholar
  • 4. Cegielska-Radziejewska R., Leśnierowski G., Kijowski J.: Propertiesand application of egg white lysozyme and its modified preparations -a review. Pol. J. Food Nutr. Sci., 2008; 58: 5-10
    Google Scholar
  • 5. Cordeiro C.M., Hincke M.T.: Recent patents on eggshell: shell andmembrane applications. Recent Pat. Food Nutr. Agric., 2011; 3: 1-8
    Google Scholar
  • 6. De Vries M., Kwakkel R.P., Kijlstra A.: Dioxins in organic eggs: a review.NJAS, 2006; 54: 207-221
    Google Scholar
  • 7. Dioxins and their effects on human health. http://www.who.int/mediacentre/factsheets/fs225/en/ (22.02.2016)
    Google Scholar
  • 8. Eftekhar S., Parsaei H., Keshavarzi Z., Yazdi A.T., Hadjzadeh M.A.,Rajabzadeh A., Malayeri S.O.: The prevention and treatment effects ofegg yolk high density lipoprotein on the formation of atherosclerosisplaque in rabbits. Iran. J. Basic Med. Sci., 2015; 18: 343-349
    Google Scholar
  • 9. Fedorova I., Hussein N., Baumann M.H., Di Martino C., Salem N. Jr.:An n-3 fatty acid deficiency impairs rat spatial learning in the Barnesmaze. Behav. Neurosci., 2009; 123: 196-205
    Google Scholar
  • 10. Geng F., Huang X., Ma M.: Hen egg white ovomacroglobulin promotesfibroblast migration via mediating cell adhesion and cytoskeleton.J. Sci. Food Agric., 2016; 96: 3188-3194
    Google Scholar
  • 11. Goldberg S., Gardener H., Tiozzo E., Ying Kuen C., Elkind M.S., SaccoR.L., Rundek T.: Egg consumption and carotid atherosclerosis in theNorthern Manhattan study. Atherosclerosis, 2014; 235: 273-280
    Google Scholar
  • 12. Hanberg A.: Compilation of EU Dioxin Exposure and Health Data.Task 8 – Human toxicology. Report produced for European CommissionEnvironment UK Department of the Environment, Transport and theRegions (DETR); 1999: 7-10
    Google Scholar
  • 13. Hap A., Kielan W., Grzebieniak Z., Siewinski M., Rudnicki J., TarnawaR., Rudno-Rudzinska J., Agrawal A.K.: Control of active B and L cathepsinsin tissues of colorectal cancer using cystatins isolated from chickenegg proteins: in vitro studies. Folia Histochem. Cytobiol., 2011; 49: 670-676
    Google Scholar
  • 14. Ibrahim H.R., Sugimoto Y., Aoki T.: Ovotransferrin antimicrobialpeptide (OTAP-92) kills bacteria through a membrane damage mechanism.Biochim. Biophys. Acta, 2000; 1523: 196-205
    Google Scholar
  • 15. Imiela J., Lewandowicz A.: Cystatyna C w diagnostyce przewlekłejchoroby nerek. Nefrol. Dial. Pol., 2007; 11: 126-132
    Google Scholar
  • 16. Janssen C.I., Kiliaan A.J.: Long-chain polyunsaturated fatty acids(LCPUFA) from genesis to senescence: The influence of LCPUFA onneural development, aging, and neurodegeneration. Prog. Lipid Res.,2014; 53: 1-17
    Google Scholar
  • 17. Jiang S.T.: Temperature-stable glycosylated recombinant chickencystatin and the use thereof. US Patent, 7078488 B2; 2006
    Google Scholar
  • 18. King’ori A.M.: A review of the uses of poultry eggshells and shellmembranes. Int. J. Poult. Sci., 2011; 10: 908-912
    Google Scholar
  • 19. Kolaczkowska A., Kolaczkowski M., Sokolowska A., MiecznikowskaH., Kubiak A., Rolka K., Polanowski A.: The antifungal properties ofchicken egg cystatin against Candida yeast isolates showing differentlevels of azole resistance. Mycoses, 2010; 53: 314-320
    Google Scholar
  • 20. Kollberg H., Carlander D., Olesen H., Wejaker P.E., Johannesson M.,Larsson A.: Oral administration of specific yolk antibodies (IgY) mayprevent Pseudomonas aeruginosa infections in patients with cystic fibrosis:a phase I feasibility study. Pediatr. Pulmonol., 2003; 35: 433-440
    Google Scholar
  • 21. Levy E., Jaskolski M., Grubb A.: The role of cystatin C in cerebralamyloid angiopathy and stroke: cell biology and animal models. BrainPathol., 2006; 16: 60-70
    Google Scholar
  • 22. Müller S., Schubert A., Zajac J., Dyck T., Oelkrug C.: IgY antibodies inhuman nutrition for disease prevention. J. Nutr., 2015, 14: 109
    Google Scholar
  • 23. Nakai S., Ogawa M., Nakamura S.: Production and use of modifiedcystatins. US Patent, 6534477 B2; 2003
    Google Scholar
  • 24. Pokora M., Zambrowicz A., Dąbrowska A., Eckert E., Setner B.,Szołtysik M., Szewczuk Z., Zabłocka A., Polanowski A., Trziszka T., ChrzanowskaJ.: An attractive way of egg white protein by-product usefor producing of novel anti-hypertensive peptides. Food Chem., 2014;151: 500-505
    Google Scholar
  • 25. Polanowski A., Sosnowska A., Zabłocka A., Janusz M., Trziszka T.:Immunomodulatory activity accompanying chicken egg yolk immunoglobulinY: separation and identification. Biol. Chem., 2013; 394: 879-887
    Google Scholar
  • 26. Pussemier L., Mohimont L., Huyghebaert A., Goeyens L.: Enhancedlevels of dioxins in eggs from free range hens; a fast evaluation approach.Talanta, 2004; 63: 1273-1276
    Google Scholar
  • 27. Siepka E., Bobak Ł., Gładkowski W.: Charakterystyka aktywnościbiologicznej fosfolipidów żółtka. Żywność Nauka Technologia Jakość,2015, 22: 15-28
    Google Scholar
  • 28. Skoczyńska A., Wojakowska A., Nowacki D., Bobak Ł., Turczyn B.,Smyk B., Szuba A., Trziszka T.: Unsaturated fatty acids supplementationreduces blood lead level in rats. Biomed Res. Int., 2015; 2015: 189190
    Google Scholar
  • 29. Sommer A., Tarwotjo I., Hussaini G., Susanto D.: Increased mortalityin children with mild vitamin A deficiency. Lancet, 1983; 322: 585-588
    Google Scholar
  • 30. Sommer A.: Vitamin A deficiency and its consequences: a field guideto detection and control. 3rd ed.; Genewa, WHO 1995: 1-8
    Google Scholar
  • 31. Szpak M., Trziszka T., Polanowski A., Gburek J., Gołąb K., JuszczyńskaK., Janik P., Malicki A., Szyplik K.: Evaluation of the antibacterial activityof cystatin against selected strains of Escherichia coli. Folia Biol.,2014; 62: 187-192
    Google Scholar
  • 32. Tizon B., Ribe E.M., Mi W., Troy C.M., Levy E.: Cystatin C protectsneuronal cells from amyloid-b-induced toxicity. J. Alzheimers Dis., 2010;19: 885-894
    Google Scholar
  • 33. Trziszka T., Różański H., Polanowski A.: Eggs as a very promisingsource of biomedical and nutraceutical preparations: a review. J. LifeSci., 2013; 7: 862-877
    Google Scholar
  • 34. Vitamin A. Fact sheet for health professionals. https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/ (26.04.2016)
    Google Scholar
  • 35. Walczak J., Bocian S., Trziszka T., Buszewski B.: Hyphenated analyticalmethods in determination of biologically active compounds inhen’s eggs. Crit. Rev. Anal. Chem., 2016; 46: 201-212
    Google Scholar
  • 36. Xu X., Gammon M.D., Zeisel S.H., Bradshaw P.T., Wetmur J.G., TeitelbaumS.L., Neugut A.I., Santella R.M., Chen J.: High intakes of cholineand betaine reduce breast cancer mortality in a population-based study.FASEB J., 2009; 23: 4022-4028
    Google Scholar
  • 37. Zambrowicz A., Dąbrowska A., Bobak Ł., Szołtysik M.: Egg yolk proteinsand peptides with biological activity. Postępy Hig. Med. Dośw.,2014; 68: 1524-1529
    Google Scholar
  • 38. Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M.,Babij K., Szewczuk Z., Trziszka T., Lubec G., Chrzanowska J.: Multifunctionalpeptides derived from an egg yolk protein hydrolysate: isolationand characterization. Amino Acids, 2015; 47: 369-380
    Google Scholar

Full text

Skip to content