Abstract

Leprosy or Hansen disease is caused by an infection of Mycobacterium leprae. The large number of undetected cases (2000-2012 years 4 mln people) remains a threat to the elimination of leprosy. Leprosy is an unheard in Poland and generally is considered a condition so “exotic” that it is not worth to spend more attention to it. Forgotten disease in developed countries still thrives in an environment of poor and uneducated. Regardless of the conclusion that in the 21st century none infectious disease should not be treated as a disease on the designated regions of the world, other than our own, it should be recalled that the M. leprae was discovered in Europe, where for many years there were leprosaria and still infectious hospitals in Great Brittan, France or Spain get patients suspected of leprosy. The mobility of the inhabitants of the globe caused by wars, ethnic conflicts or a simple tourism causes that any infectious disease can not be treated as solely limited to distant us regions. The best proof of this were the viral diseases, formerly found in only in Asia or Africa, and currently transmitted to Europe [1]. At any moment, we can stand up against the problem of diagnostics of humans toward leprosy. Many medical reports indicate that leprosy as a disease with many symptoms encountered difficulties in its diagnosis. Only the experience of medical professionals and good microbiological diagnosis may speed up the diagnosis of leprosy.

References

• 1. Abide J.M., Webb R.M., Jones H.L., Young L.: Three indigenous cases of leprosy in the Mississippi delta. South. Med. J., 2008; 101: 635-638
  Google Scholar
• 2. Amezcua M.E., Escobar-Gutiérrez A., Storrs E.E., Dhople A.M., Burchfield H.P.: Wild Mexican armadillo with leprosy-like infection. Int. J. Lepr. Other Mycobact. Dis., 1984; 52: 254-255
  Google Scholar
• 3. Augustynowicz-Kopeć E., Zwolska Z.: Wybrane zagadnienia biologii Mycobacterium leprae. Postępy Nauk Medycznych, 2011; 24: 895-903
  Google Scholar
• 4. Blake L.A., West B.C., Lary C.H., Todd J.R.: Environmental nonhuman sources of leprosy. Rev. Infect. Dis., 1987; 9: 562-577
  Google Scholar
• 5. Blok D.J., De Vlas S.J., Richardus J.H.: Global elimination of leprosy by 2020: are we on track? Parasit. Vectors, 2015; 8: 548
  Google Scholar
• 6. Buttigieg G.G., Savona-Ventura C., Stafrace K.M.: History of leprosy in Malta. Malta Med. J., 2008; 20: 34-38
  Google Scholar
• 7. Camacho I.D., Valencia I., Rivas M.P., Burdick A.E.: Type 1 leprosy reaction manifesting after discontinuation adalimumab therapy. Arch. Dermatol., 2009; 145: 349-351
  Google Scholar
• 8. Czubek M., Roszkiewicz J., Sopolińska E., Szczerkowska-Dobosz A., Berbeka-Siedlewicz A.: Dapson wczoraj i dziś. Dermatologia Kliniczna, 2004; 6: 23-28
  Google Scholar
• 9. Deps P.D., Alves B.L., Gripp C.G., Aragao R.L., Guedes B., Filho J.B., Andreatta M.K., Marcari R.S., Prates I., Rodrigues L.C.: Contact with armadillos increases the risk of leprosy in Brazil: a case control study. Indian J. Dermatol. Venereol. Leprol., 2008; 74: 338-342
  Google Scholar
• 10. Desikan K.V., Sreevatsa: Extended studies on viability of M. leprae outside the human body. Lepr. Rev., 1995; 66: 287-295
  Google Scholar
• 11. Donoghue H.D., Spigelman M., Greenblatt C.L., Lev-Maor G., Bar-Gal G.K., Matheson C., Vernon K., Nerlich A.G., Zink A.R.: Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNA. Lancet Infect. Dis., 2004; 4: 141-147
  Google Scholar
• 12. Ezzedine K., Malvy D., Beylot C., Longy-Boursier M.: Autochthonous leprosy in metropolitan France presenting with a diffuse infiltration of the face and febrile illness. Int. J. Dermatol., 2009; 48: 69-72
  Google Scholar
• 13. Fine P.E.: Leprosy: the epidemiology of a slow bacterium. Epidemiol. Rev., 1982; 4: 161-188
  Google Scholar
• 14. Firek J.: Trąd. W: Choroby zakaźne i pasożytnicze. Red. J. Cianciara, J. Juszczyk, wyd. Czelej Lublin 2012: 599
  Google Scholar
• 15. Franzblau S.G., Harris E.B.: Biophysical optima for metabolism of Mycobacterium leprae. J. Clin. Microbiol., 1988; 26: 1124-1129
  Google Scholar
• 16. Gomez-Valero L., Rocha E.P., Latorre A., Silva F.J.: Reconstructing the ancestor of Mycobacterium leprae: the dynamic of gene loss and genome reduction. Genome Res., 2007; 17: 1178-1185
  Google Scholar
• 17. Gormus B.J., Xu K., Baskin G.B., Martin L.N., Bohm R.P. Jr, Blanchard J.L., Mack P.A., Ratterree M.S., Meyers W.M., Walsh G.P.: Experimental leprosy in rhesus monkeys: transmission, susceptibility, clinical and immunological findings. Lepr. Rev., 1998; 69: 235-245
  Google Scholar
• 18. Haas C.J., Zink A., Palfi G., Szeimies U., Nerlich A.: Detection of leprosy in ancient human skeletal remains by molecular identification of Mycobacterium leprae. Am. J. Clin. Pathol., 2000; 114: 428-436
  Google Scholar
• 19. Han X.Y., Sizer K.C., Thompson E.J., Kabanja J., Li J., Hu P., GómezValero L., Silva F.J.: Comparative sequence analysis of Mycobacterium leprae and the New leprosy-causing Mycobacterium lepromatosis. J. Bacteriol., 2009; 191: 6067-6074
  Google Scholar
• 20. Kazda J.: Occurrence of non-cultivable acid-fast bacilli in the environment and their relationship to M. leprae. Lepr. Rev., 1981; 52, Suppl. 1: 85-91
  Google Scholar
• 21. Kazda J., Ganapati R., Revankar C., Buchanan T.M., Young D.B., Irgens L.M.: Isolation of environment – derived M. leprae from soil in Bombay. Lepr. Rev., 1986; 57, Suppl. 3: 201-208
  Google Scholar
• 22. Kazda J., Irgens L.M., Müller K.: Isolation of non-cultivable acidfast bacilli in sphagnum and moss vegetation by foot pad technique in mice. Int. J. Lepr. Other Mycobact. Dis., 1980; 48: 1-6
  Google Scholar
• 23. Kerr-Pontes L.R, Barreto M.L., Evangelista C.M., Rodrigues L.C., Heukelbach J., Feldmeier H.: Socioeconomic, environmental, and behavioural risk factors for leprosy in North-east Brazil: results of a case-control study. Int. J. Epidemiol., 2006; 35: 994-1000
  Google Scholar
• 24. Kirchheimer W.F., Storrs E.E.: Attempts to establish the armadillo (Dasypus novemcinctus Linn.) as a model for the study of leprosy. I. Report of lepromatoid leprosy in an experimentally infected armadillo. Int. J. Lepr. Other Mycobact. Dis., 1971; 39: 693-702
  Google Scholar
• 25. Kowalska M.: Reakcje trądowe: niebezpieczne powikłania, trudności interpretacyjne i lecznicze. Przegl. Dermatol., 2009; 96: 27-35
  Google Scholar
• 26. Lahiri R., Krahenbuhl J.L.: The role of free-living pathogenic amoeba in the transmission of leprosy: a proof of principle. Lepr. Rev., 2008; 79: 401-409
  Google Scholar
• 27. Lavania M., Katoch K., Parashar D., Sharma P., Das R, Chauhan D.S, Sharma V.D., Katoch V.M.: Predominance of Mycobacterium fortuitum-chelonae complex in Ghatampur field area, endemic for leprosy. Indian J. Lepr., 2008; 80: 323-330
  Google Scholar
• 28. Lewis F.S.: Dermatologic manifestations of leprosy 2011. emedicine.medscape.com/article/1104977-clinical
  Google Scholar
• 29. Marri P.R., Bannantine J.P., Golding G.B.: Comparative genomics of metabolic pathways in Mycobacterium species: gene duplication, gene decay and lateral gene transfer. FEMS Microbiol. Rev., 2006; 30: 906-925
  Google Scholar
• 30. Matsuoka M., Izumi S., Budiawan T., Nakata N., Saeki K.: Mycobacterium leprae DNA in daily using water as a possible source of leprosy infection. Indian J. Lepr., 1999; 71: 61-67
  Google Scholar
• 31. Medeiros S., Catorze M.G., Vieira M.R.: Hansen’s disease in Portugal: multibacillary patients treated between 1988 and 2003. J. Eur. Acad. Dermatol. Venereol., 2009; 23: 29-35
  Google Scholar
• 32. Meima A., Smith W.C., van Oortmarssen G.J., Richardus J.H., Habbema J.D.: The future incidence of leprosy: a scenario analysis. Bull. WHO, 2004; 82: 373-380
  Google Scholar
• 33. Mostafa H.M., Kazda J., Irgens L.M., Luesse H.G.: Acid-fast bacilli from former leprosy regions in coastal Norway showing PCR positivity for Mycobacterium leprae. Int. J. Lepr. Other Mycobact. Dis., 1995; 63: 97-99
  Google Scholar
• 34. Naafs B.: Leprosy after the year 2000. Trop. Med. Int. Health, 2000; 5: 400-403
  Google Scholar
• 35. Neonakis I.K., Gitti Z., Kontos F., Baritaki S., Zerva L., Krambovitis E., Spandidos D.A.: Report of 2 indigenous cases of leprosy from a European country: use of polymerase chain reaction-restriction fragment length polymorphism analysis of hsp65 gene for identification of Mycobacterium leprae directly from a clinical sample. Diagn. Microbiol. Infect. Dis., 2009; l64: 331-333
  Google Scholar
• 36. Pardal-Fernández J.M., Rodríguez-Vázquez M., FernándezAragón G., Iñíguez-De Onzoño L., García-Muñozguren S.: Leprosy and severe neuropathy in two native Spaniards. Rev. Neurol., 2007; 45: 734-738
  Google Scholar
• 37. Passak-Stańda G.: Diagnostyka mikrobiologiczna gruźlicy w województwie małopolskim. Dzieje dawne i współczesność. Walka z gruźlicą u ludzi i zwierząt w Polsce. Stulecie pierwszego polskiego laboratorium prątka Rudka 1912-2012, red. H. Dusińska, Z. Zwolska, wyd. KAWDRUK Warszawa 2012: 69-78
  Google Scholar
• 38. Płusa T.: Współczesne zagrożenia zakażeniami wirusowymi. Nowa Medycyna, 2009; 3: 178-184
  Google Scholar
• 39. Rafi A., Spigelman M., Stanford J., Lemma E., Donoghue H., Zias J.: Mycobacterium leprae DNA from ancient bone detected by PCR. Lancet, 1994; 343: 1360-1361
  Google Scholar
• 40. Rambukkana A.: How does Mycobacterium leprae target the peripheral nervous system? Trends Microbiol., 2000; 8: 23-28
  Google Scholar
• 41. Report of the International Leprosy Association Technical Forum, Paris, France, 2002. Epidemiology and control. Int. J. Lepr Other Mycobact. Dis., 2002; 70, Suppl. 1: 546-552
  Google Scholar
• 42. Saha K., Jain M., Mukherjee M.K., Chawla N.M., Chaudhary D.S., Prakash N.: Viability of Mycobacterium leprae within the gut of Aedes aegypti after they feed on multibacillary lepromatous patients: a study by fluorescent and electron microscopes. Lepr. Rev., 1985; 56: 279-290
  Google Scholar
• 43. Scollard D.M., Joyce M.P., Gillis T.P.: Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases. Clin. Infect. Dis., 2006; 43: e19-e22
  Google Scholar
• 44. Skinses O.K.: Origin of Chaulmoogra oil – another version. Int. J. Lepr. Other Mycobact. Dis., 1972; 40: 172-173
  Google Scholar
• 45. Sreevatsa: Leprosy and arthropods. Indian J. Lepr., 1993; 65: 189-200
  Google Scholar
• 46. Sterne J.A., Pönnighaus J.M., Fine P.E., Malema S.: Geographic determinants of leprosy in Karonga District, Northern Malawi. Int. J. Epidemiol., 1995; 24: 1211-1222
  Google Scholar
• 47. Szałkowska E.: Światowy dzień Walki z Trądem – dniem solidarności z trędowatymi. Kurier Wileński beta, 2012; 26.01
  Google Scholar
• 48. Taylor C.E., Elliston E.P., Gideon H.: Asymptomatic infections in leprosy. Int. J. Lepr., 1965; 33: 716-731
  Google Scholar
• 49. The Leprosy Archives in Bergen, Norway. http://digitalarkivet. uib.no/lepra-eng/intro.htm (30.05.2009)
  Google Scholar
• 50. Truman R., Fine P.E.: „Environmental” sources of Mycobacterium leprae: issues and evidence. Lepr. Rev., 2010; 81: 89-95
  Google Scholar
• 51. Truman R.W., Shannon E.J., Hagstad H.V., Hugh-Jones M.E., Wolff A., Hastings R.C.: Evaluation of the origin of Mycobacterium leprae infections in the wild armadillo, Dasypus novemcinctus. Am. J. Trop. Med. Hyg., 1986; 35: 588-593
  Google Scholar
• 52. Walsh G.P., Meyers W.M., Binford C.H.: Naturally acquired leprosy in the nine-banded armadillo: a decade of experience 1975-1985. J. Leukoc. Biol., 1986; 40: 645-656
  Google Scholar
• 53. Watson C., Lockwood D.N.: Single nucleotide polymorphism analysis of European archeological M. leprae DNA. PLoS One, 2009; 4: e7547
  Google Scholar
• 54. Wheeler P.R.: Metabolism in Mycobacterium leprae: its relation to other research on M. leprae and to aspects of metabolism in other mycobacteria and intracellular parasites. Int. J. Lepr. Other Mycobact. Dis., 1984; 2: 208-230
  Google Scholar
• 55. WHO – Global leprosy situation. Sept.1999. Weekly Epidemiological Record, 1999; 74: 313-320
  Google Scholar
• 56. Zwolska Z.: Stulecie mikrobiologicznej diagnostyki gruźlicy w Polsce. W: Towarzystwa naukowe w Polsce, dziedzictwo, kultura, nauka, trwanie. Wyd. Rada Towarzystw Naukowych przy Prezydium PAN, Warszawa 2013, Tom 2: 307-321
  Google Scholar

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