The impact of gluten ingestion on pathogenesis of neurological disorders

REVIEW ARTICLE

The impact of gluten ingestion on pathogenesis of neurological disorders

Piotr Grzegrzółka 1 , Robert Jarzyna 1

1. Zakład Regulacji Metabolizmu, Instytut Biochemii, Wydział Biologii Uniwersytetu Warszawskiego,

Published: 2019-01-07
DOI: 10.5604/01.3001.0013.1936
GICID: 01.3001.0013.1936
Available language versions: en pl
Issue: Postepy Hig Med Dosw 2019; 73 : 197-216

 

Abstract

For many years the spectrum of gluten-related disorders had been limited only to celiac disease and its typical gastrointestinal symptoms. In the last few years, not only new disorders like non-celiac gluten sensitivity have been described, but also pathogeneses of celiac disease and wheat allergy have been better understood. It is also known that impaired gluten tolerance in many cases leads to appearance of extraintestinal symptoms that may affect any organ or system of the human body including the nervous system that may be the cause of some neurological disorders such as ataxia, neuropathy, autism spectrum disorder (ASD) or schizophrenia. In this paper we present the spectrum of neurological disorders, whose pathogeneses may depend on gluten ingestion and some proposed mechanisms elucidating those pathogeneses.

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