Abstract

Approximately 10% of couples have difficulties conceiving. Idiopathic infertility affects 10–15% of infertile couples. Some suspected causes of idiopathic infertility are lifestyle factors such as stress, diet, smoking, obesity, lack of physical exercise and alcohol consumption. At the same time, allergies and bronchial asthma are growing health problems in developed countries. Therefore, this study addresses the possible correlation between atopic diseases and fertility. Several interesting cases of patients presenting symptoms of HSPH (human seminal plasma hypersensitivity) have been reported to date. In the majority of cases, allergy to semen is the IgE-dependent response to proteins contained in the seminal plasma. Observations indicating that patients presenting symptoms of HSPH are primarily allergic to allergens of dogs are particularly interesting. The structure of dog allergen Can f 5 is similar to the human PSA (55–60% similarity in the sequence of amino acids). This may explain the presence of IgE-dependent reactions following contact with semen during sexual intercourse in women allergic to dog fur. This article presents the current state of knowledge on the phenomenon.

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