The role of linoleic and α-linolenic acids and their metabolites in maintaining chronic inflammation and developing colorectal cancer
Katarzyna Walkiewicz 1 , Karolina Janion 2 , Monika Gętek-Paszek 3 , Ewa Nowakowska-Zajdel 1Abstract
For many years it has been postulated the role of dietary factors, in particular the consumption of fatty acids, in the development of cancer. It has been confirmed in numerous epidemiological observations, as well as the experimental studies on cell lines. Despite numerous studies the role of various fatty acids and their metabolites, has not been clearly established. Among others there are still under investigation on the importance of linoleic acid, belonging to the group of polyunsaturated omega-6. Because of the diversity of scientific reports authors of this publication are trying to make a critical synthesis analysis of current knowledge of the postulated role of linoleic acid in development of colon cancer. And they also attempt to draw practical conclusions from them. The ability to modify their lifestyle, including dietary habits, and their real impact on the development of malignancies is a very important area of research, and can have an impact on the cancer epidemiology. Based on currently available data, dietary recommendations can be made for individual polyunsaturated fatty acid. It is recommended that in adults the LA share was 4% of the energy value of the diet, while the α-linolenic acid share was 0.5% of the energy value of the diet. In addition, in order to provide the right amount of docosahexaenoic acid and eicosapentaenoic acid, it is recommended to include at least 2 portions of fish per week, including 1 portion of oily fish.
References
- 1. Abdolmaleki F., Kovanen P.T., Mardani R., Gheibi-Hayat S.M., BoS., Sahebkar A.: Resolvins: Emerging players in autoimmune andinflammatory diseases. Clin. Rev. Allergy Immunol., 2020; 58: 82–91 2 Bautista D., Obrador A., Moreno V., Cabeza E., Canet R., BenitoE., Bosh X., Costa J.: Ki-ras mutation modifies the protective effectof dietary monounsaturated fat and calcium on sporadic colorectalcancer. Cancer Epidemiol. Biomarkers Prev., 1997; 6: 57–61
Google Scholar - 2. represses gene expression: Evidence of role inacute-phase inflammatory response. Arterioscler. Thromb. Vasc.Biol., 2002; 22: 1631–1636
Google Scholar - 3. Brink M., Weijenberg M.P., De Goeij A.F., Schouten L.J., KoedijkF.D., Roemen G.M., Lentjes M.H., De Bruïne A.P., Goldbohm R.A.,Van Den Brandt P.A.: Fat and K-ras mutations in sporadic colorectalcancer in The Netherlands Cohort Study. Carcinogenesis,2004; 25: 1619–1628
Google Scholar - 4. Broughton K.S., Johnson C.S., Pace B.K., Liebman M., KleppingerK.M.: Reduced asthma symptoms with n-3 fatty acid ingestion arerelated to 5-series leukotriene production. Am. J. Clin. Nutr., 1997;65: 1011–1017
Google Scholar - 5. Burdan F., Chałas A., Szumiło J.: Cyclooxygenase and prostanoids– biological implications. Postępy Hig. Med. Dośw., 2006;60: 129–141
Google Scholar - 6. Caygil C.P., Charlett A., Hill M.J.: Fat, fish, fish oil and cancer.Br. J. Cancer, 1996; 74: 159–164
Google Scholar - 7. Cichosz G., Czeczot H.: Rzekomo zdrowe tłuszcze roślinne. Pol.Merk. Lek. 2011; 31: 184–239
Google Scholar - 8. de Lorgeril M., Renaud S., Mamelle N., Salen P., Martin J.L.,Guidollet J., Touboul P., Delay J.: Mediterranean alpha-linolenicacid-rich diet in secondary prevention of coronary heart disease.Lancet, 1994; 343: 1454–1459
Google Scholar - 9. Diergaarde B., van Geloof W.L., van Muijen G.N., Kok F.J., KampmanE.: Dietary factors and the occurrence of truncating APC mutationsin sporadic colon carcinomas: A Dutch population-basedstudy. Carcinogenesis, 2003; 24: 283–290
Google Scholar - 10. Ferruci L., Cherubini A., Bandinelli S., Bartali B., Corsi A., LauretaniF., Martin A., Andres-Lacueva C., Senin U., Guralnik J.M.: Relationshipof plasma polyunsaturated fatty acids to circulating inflammatorymarkers. J. Clin. Endocrinol. Metab., 2006; 91: 439–446
Google Scholar - 11. Giuliani A., Ferrara F., Scimò M., Angelico F., Olivieri L., BassoL.: Adipose tissue fatty acid composition and colon cancer: A casecontrolstudy. Eur. J. Nutr., 2014; 53: 1029–1037
Google Scholar - 12. Hanse-Petrik M.B, McEntee M.F., Jull B., Shi H., Zemel M.B.,Whelan J.: Prostaglandin E2 protects intestinal tumors from nonsteroidalanti-inflammatory drug-induced regression in ApcMin/+mice. Cancer Res., 2002; 62: 403–408
Google Scholar - 13. Janion K., Copija A., Walkiewicz K., Nowakowska-Zajdel E.:Rak jelita grubego u osób starszych – znaczenie peroksydacji lipidóww procesach nowotworzenia. Post. Diet. Geriat. Gerontol.,2016; 4: 48–52
Google Scholar - 14. Jelińska M.: Kwasy tłuszczowe – czynniki modyfikujące procesynowotworowe. Biul. Wydz. Farm. AMW, 2005; 1: 1–9
Google Scholar - 15. Jelińska M., Tokarz A., Brzóska J.: Tłuszcze diety a zawartośćHETE i HODE w mikrosomach wątrobowych szczurów. Bromat.Chem. Toksykol., 2010; 3: 330–335
Google Scholar - 16. Koh W.P, Yuan J.M, van der Berg D., Lee H.P., Yu M.C.: Interactionbetween cyclooxygenase-2 gene polymorphism and dietaryn-6 polyunsaturated fatty acids on colon cancer risk: The SingaporeChinese Health Study. Br. J. Cancer, 2004; 90: 1760–1764
Google Scholar - 17. Levi F., Pasche C., Lucchini F., Vecchia C.L.: Macronutrientsand colorectal cancer: A Swiss case-control study. Ann. Oncol.,2002; 13: 369–373
Google Scholar - 18. Lu X.F., He G.Q., Yu H.N., Ma Q., Shen S.R., Das U.N.: Colorectalcancer cell growth inhibition by linoleic acid is related to fatty acidcomposition changes. J. Zhejiang Univ. Sci. B., 2010; 11: 923–930
Google Scholar - 19. Lu X., Yu H., Ma Q., Shen S., Das, U.N.: Linoleic acid suppressescolorectal cancer cell growth by inducing oxidant stress and mitochondrialdysfunction. Lipids Health Dis., 2010; 9: 106
Google Scholar - 20. Łacheta D., Olejarz W., Włodarczyk M., Nowicka G.: Wpływkwasu dokozaheksaenowego (DHA) i eikozapentaenowego (EPA)na regulację funkcji komórek śródbłonka naczyniowego. PostępyHig. Med. Dośw., 2019; 73: 467–475
Google Scholar - 21. Ma Y., Yang Y., Wang F., Zhang P., Shi C., Zou Y., Qin H.: Obesityand risk of colorectal cancer: A systematic review of prospectivestudies. PLoS One, 2013; 8: e53916
Google Scholar - 22. Marciniak-Łukasiak K.: Rola i znaczenie kwasów tłuszczowychomega-3. Żywn. Nauka Tech. Jakość, 2011; 6: 24–35
Google Scholar - 23. Matsuoka T., Adair J.E., Lih F.B., Hsi L.C., Rubino M., Eling T.E.,Tomer K.B., Yashiro M., Hirakawa K., Olden K., Roberts J.D.: Elevateddietary linoleic acid increases gastric carcinoma cell invasion andmetastasis in mice. Br. J. Cancer, 2010; 103: 1182–1191
Google Scholar - 24. Mocellin M.C., Camargo C.Q., Nunes E.A., Fiates G.M., TrindadeE.B.: A systematic review and meta-analysis of the n-3 polyunsaturatedfatty acids effects on inflammatory markers in colorectalcancer. Clin. Nutr., 2016; 35: 359–369
Google Scholar - 25. Mormile R., Vittori G., De Michele M., Squarcia U., Quani F.:Linoleic acid and colorectal cancer cell growth suppression: is thederegulation of mitochondrial survivin the key factor? Int. J. ColorectalDis., 2012; 27: 1383–1384
Google Scholar - 26. Muc-Wierzgoń M., Nowakowska-Zajdel E., Dzięgielewska-Gęsiak S., Kokot T., Klakla K., Fatyga E., Grochowska-NiedworokE., Waniczek D., Wierzgoń J.: Specific metabolic biomarkers as riskand prognostic factors in colorectal cancer. World J. Gastroenterol.,2014; 20: 9759–9774
Google Scholar - 27. Nishioka N., Matsuoka T., Yashiro M., Hirakawa K., Olden K.,Roberts J.D.: Linoleic acid enhances angiogenesis through suppressionof angiostatin induced by plasminogen activator inhibitor 1 Br. J. Cancer, 2011; 105: 1750–1758
Google Scholar - 28. Nowak J.Z.: Przeciwzapalne „prowygaszeniowe” pochodnewielonienasyconych kwasów tłuszczowych omega 3 i omega 6.Postępy Hig. Med. Dośw., 2010; 64: 115–132
Google Scholar - 29. Nowakowska-Zajdel E., Mazurek U., Ziółko E., Niedworok E.,Fatyga E., Kokot T., Muc-Wierzgoń M.: Analysis of expression profileof gene encoding proteins of signal cascades activated by insulinlikegrowth factors in colorectal cancer. Int. J. Immunopathol.Pharmacol., 2011; 24: 781–787
Google Scholar - 30. Papafili A., Hill M.R., Brull D.J, McAnulty R.J., Marshall R.P.,Humphries S.E., Laurent G.J.: Common promoter variant in cyclooxygenase-
Google Scholar - 31. Ribioli E.: The European Prospective Investigation into Cancerand Nutrition (EPIC): Plans and progress. J. Nutr., 2001; 131:170S–175S
Google Scholar - 32. Schloss I., Kidd M.S., Tichelaar H.Y, Young G.O., O’Keefe S.J.:Dietary factors associated with a low risk of colon cancer in colouredWest Coast fishermen. S. Afr. Med. J., 1997; 87: 152–158
Google Scholar - 33. Shimomoto T., Luo Y., Ohmori H., Chihara Y., Fujii K., SasahiraT., Denda A., Kuniyasu H.: Advanced glycation end products (AGE)induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and highglucosediet. J. Gastroenterol., 2012; 47: 1073–1083
Google Scholar - 34. Simopoulos A.P.: Omega-3 fatty acids and cardiovascular disease:The epidemiological evidence. Environ. Health Prev. Med.,2002; 6: 203–209
Google Scholar - 35. Simopoulos A.P.: Omega-3 fatty acids in health and disease andin growth and development. Am. J. Clin. Nutr., 1991; 54: 438–463
Google Scholar - 36. Simopoulos A.P.: The importance of the omega-6/omega-3fatty acid ratio in cardiovascular disease and other chronic diseases.Exp. Biol. Med., 2008; 233: 674–688
Google Scholar - 37. Thun M.J, Namboordi M.M, Heath C.W.Jr.: Aspirin use andreduced risk of fatal colon cancer. N. Engl. J. Med., 1991; 325: 1593–1596
Google Scholar - 38. Wang W., Yang H., Johnson D., Gensler C., Decker E., Zhang G.:Chemistry and biology of ω-3 PUFA peroxidation-derived compounds.Prostaglandins Other Lipid Mediat., 2017; 132: 84–91
Google Scholar - 39. Weijenberg M.P., Lüchtenborg M., De Goeij A.F., Brink M., vanMuijen G.N., deBruine A.P., Goldbohm R.A., van den Brandt P.A.:Dietary fat and risk of colon and rectal cancer with aberrant MLH1expression, APC or KRAS genes. Cancer Causes Control., 2007; 18:865–879
Google Scholar - 40. Whelan J., McEntee M.F.: Dietary (n-6) PUFA and intestinaltumorigenesis. J. Nutr., 2004; 134: 3421S–3426S
Google Scholar - 41. Yang B., Ren X.L., Fu Y.Q., Gao I.L., Li D.: Ratio of n-3/n-6 PUFAsand risk of breast cancer: A meta-analysis of 274135 adult femalesfrom 11 independent prospective studies. BMC Cancer, 2014; 14: 105
Google Scholar - 42. Yang K., Li H., Dong J., Dong Y., Wang C.Z.: Expression profileof polyunsaturated fatty acids in colorectal cancer. World J. Gastroenterol.,2015; 21: 2405–2412
Google Scholar - 43. Zampelas A., Paschos G., Rallidis L., Yiannakouris N.: Linoleicacid to alpha-linolenic acid ratio. From clinical trials to inflammatorymarkers of coronary artery disease. World Rev. Nutr. Diet.,2003; 92: 92–108
Google Scholar - 44. Zhao G., Etherton T.D., Martin K.R., West S.G., Gillies P.J., Kris-Etherton P.M.: Dietary α-linolenic acid reduces inflammatory andlipid cardiovascular risk factors in hypercholesterolemic men andwomen. J. Nutr., 2004; 134: 2991–2997
Google Scholar