Abstract

Protein content in cow milk (with over 20 proteins, and peptides may also occur as a result of enzymatic hydrolysis) ranges from 2.5% to 4.2% and is about 1.5-2 times higher than in human milk. Its most important allergens are considered to be β-lactoglobulin (absent in human milk) and αs1-casein. The most similar in composition to human milk is horse and donkey milk. It contains considerably more whey proteins (35-50%) than cow milk (about 20%), and the concentration of the most allergenic casein fraction αs1 is 1.5-2.5 g/l. In comparison, the content of αs1-casein in cow milk is about 10 g/l. β-lactoglobulin present in donkey milk is a monomer, while in milk of ruminants it is a dimer. Like human milk, it contains a substantial amount of lactose (about 7%), which determines its flavour and facilitates calcium absorption. The high lysozyme content (about 1 g/l) gives it antibacterial properties (compared to trace amounts in ruminants). Camel milk is also more digestible and induces fewer allergic reactions, because it lacks β-lactoglobulin, and its β-casein has a different structure. It also contains (compared to cow milk) more antibacterial substances such as lysozyme, lactoferrin and immunoglobulins, and furthermore the number of immunoglobulins is compatible with human ones. Goat milk components have a higher degree of assimilability as compared to cow milk. Its main protein is β-casein, with total protein content depending on the αs1-casein genetic variant. Goats with the ‘0’ variant do not synthesize this allergenic protein. Clinical and immunochemical studies indicate, however, that it cannot be a substitute for cow milk without the risk of an anaphylactic reaction.

References

• 1. Abbas S., Ashraf H., Nazir A., Sarfraz L.: Physico-chemical analysisand composition of camel milk. Int. Res., 2013; 2: 84-98
  Google Scholar
• 2. Armaforte E., Curran E., Huppertz T., Ryan A., Caboni M.F., O’ConnorP.M., Ross R.P., Hirtz C., Sommerer N., Chevalier F., Kelly A.L.:Proteins and proteolysis in pre-term and term human milk and possibleimplications for infant formulae. Int. Dairy J., 2010; 20: 715-723
  Google Scholar
• 3. Balińska-Miśkiewicz W.: Diagnostyka molekularna alergii pokarmowej– czy wiemy więcej? Postępy Hig. Med. Dośw., 2014; 68: 754-767
  Google Scholar
• 4. Barłowska J., Litwińczuk Z., Kędzierska-Matysek M., LitwińczukA.: Polymorphism of caprine milk αs1-casein in relation to performanceof four Polish goat breeds. Pol. J. Vet. Sci., 2007; 10: 159-164
  Google Scholar
• 5. Barłowska J., Szwajkowska M., Litwińczuk Z., Król J.: Nutritionalvalue and technological suitability of milk from various animalspecies used for dairy production. Compr. Rev. Food Sci. F., 2011;10: 291-302
  Google Scholar
• 6. Barłowska J., Wolanciuk A., Kędzierska-Matysek M., LitwińczukZ.: Wpływ sezonu produkcji na podstawowy skład chemiczny orazzawartość makro – i mikroelementów w mleku krowim i kozim.Zywn-Nauk. Technol. Ja., 2013; 6: 69-78
  Google Scholar
• 7. Barłowska J., Wolanciuk A., Litwińczuk Z., Król J.: Milk proteins’polymorphism in various species of animals associated with milkproduction utility. W: Milk Protein, red.: Hurley W.L. In Tech – OpenAccess Publisher, Rijeka, 2012, 235-264
  Google Scholar
• 8. Björkstén B., Clayton T., Ellwood P., Stewart A., Strachan D., ISAACPhase III Study Group: Worldwide time trends for symptomsof rhinitis and conjunctivitis: Phase III of the International Studyof Asthma and Allergies in Childhood. Pediatr. Allergy Immunol.,2008; 19: 110-124
  Google Scholar
• 9. Bonizzi I., Buffoni J.N., Feligini M.: Quantification of bovine caseinfractions by direct chromatographic analysis of milk. Approachingthe application to a real production context. J. Chromatogr.A, 2009; 1216: 165-168
  Google Scholar
• 10. Brodziak A., Król J., Barłowska J., Litwińczuk Z.: Effect of productionseason on protein fraction content in milk of various breeds ofgoats in Poland. Int. J. Dairy Technol., 2014; 67: 410-419
  Google Scholar
• 11. Businco L., Giampietro P.G., Lucenti P., Lucaroni F., Pini C., DiFelice G., Iacovacci P., Curadi C., Orlandi M.: Allergenicity of mare’smilk in children with cow’s milk allergy. J. Allergy Clin. Immunol.,2000; 105: 1031-1034
  Google Scholar
• 12. Caira S., Pizzano R., Picariello G., Pinto G., Cuollo M., ChianeseL., Addeo F.: Allergenicity of milk proteins. W: Milk Protein, red.:Hurley W.L., In Tech – Open Access Publisher, Rijeka 2012, 173-214
  Google Scholar
• 13. Claeys W.L., Verraes C., Cardoen S., De Block J., Huyghebaert A.,Raes K., Dewettinck K., Herman L.: Consumption of raw or heatedmilk from different species: an evaluation of the nutritional andpotential health benefits. Food Control, 2014; 42: 188-201
  Google Scholar
• 14. Costanzo A.: Characterization of donkey milk proteins by a proteomicapproach. Università Degli Studi Di Napoli “Federico II”, 2013 http://www.fedoa.unina.it/9122/1/costanzo_angela_25.PDF(29.06.2015)
  Google Scholar
• 15. Cunsolo V., Muccilli V., Saletti R., Foti S.: MALDI-TOF mass spectrometryfor the monitoring of she-donkey’s milk contamination oradulteration. J. Mass Spectrom., 2013; 48: 148-153
  Google Scholar
• 16. D’Alessandro A.G., Martemucci G., Jirillo E., De Leo V.: Majorwhey proteins in donkey’s milk: effect of season and lactation stage.Implications for potential dietary interventions in human diseases.Immunopharmacol. Immunotoxicol., 2011; 33: 259-265
  Google Scholar
• 17. Dubakiene R., Rudzeviciene O., Butiene I., Sezaite I., PetronyteM.A., Vaicekauskaite D., Zvirbliene A.: Studies on early allergic sensitizationin the Lithuanian birth cohort. Scientific World Journal,2012; 2012: 909524
  Google Scholar
• 18. El-Agamy E.I.: The challenge of cow milk protein allergy. SmallRuminant Res., 2007; 68: 64-72
  Google Scholar
• 19. El-Hatmi H., Girardet J-M., Gaillard J-L., Yahyaoui M.H., Attia H.:Characterisation of whey proteins of camel (Camelus dromedarius)milk and colostrum. Small Ruminant Res., 2007; 70: 267-271
  Google Scholar
• 20. Epidemiologia Chorób Alergicznych w Polsce – ECAP. http://ecap.pl/material.html (12.07.2015)
  Google Scholar
• 21. Fiocchi A., Brozek J., Schünemann H., Bahna S.L., von Berg A., BeyerK., Bozzola M., Bradsher J., Compalati E., Ebisawa M., Guzmán M.A., Li H.,Heine R.G., Keith P., Lack G. i wsp.: World Allergy Organization (WAO)Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA)Guidelines. Pediatr. Allergy Immunol., 2010; 21 (Suppl. 21): 1-125
  Google Scholar
• 22. Gaudin J.C., Rabesona H., Choiset Y., Yeretssian G., Chobert J.M.,Sakanyan V., Drouet M., Haertlé T.: Assessment of the immunoglobulinE-mediated immune response to milk-specific proteins in allergicpatients using microarrays. Clin. Exp. Allergy, 2008; 38: 686-693
  Google Scholar
• 23. Gobesso A.A., Gonzaga I.V., Taran F.M., Françoso R., Centini T.N.,Moreira C.G., Ferreira J.R., Rodrigues F.P., Baldi F.: Influence of fatsupplementation on mare’s milk composition. W: Forages and grazingin horse nutrition, red.: Saastamoinen M. i wsp., EAAP publicationNo. 132, Wageningen Academic Publishers, The Netherlands,2012, 347-350
  Google Scholar
• 24. Gubić J.M., Šarić L.Ć., Šarić B.M., Mandić A.I., Jovanov P.T., PlavšićD.V., Okanović D.G.: Microbiological, chemical and sensory propertiesof domestic donkey’s milk from autochthones Serbian breed. J.Food Nutr. Res., 2014; 2: 633-637
  Google Scholar
• 25. Guo H.Y., Pang K., Zhang X.Y., Zhao L., Chen S.W., Dong M.L.,Ren F.Z.: Composition, physiochemical properties, nitrogen fractiondistribution, and amino acid profile of donkey milk. J. DairySci., 2007; 90: 1635-1643
  Google Scholar
• 26. Ha M., Bekhit A. El-Din, McConnell M., Mason S., Carne A.: Fractionationof whey proteins from red deer (Cervus elaphus) milk andcomparison with whey proteins from cow, sheep and goat milks.Small Ruminant Res., 2014; 120: 125-134
  Google Scholar
• 27. Haenlein G.F.: Goat milk in human nutrition. Small RuminantRes., 2004; 51: 155-163
  Google Scholar
• 28. Hamed H., Trujillo A.J., Juan B., Guamis B., ElFeki A., GargouriA.: Interrelationships between somatic cell counts, lactation stageand lactation number and their influence on plasmin activity andprotein fraction distribution in dromedary (Camelus dromedaries) andcow milks. Small Ruminant Res., 2012; 105: 300-307
  Google Scholar
• 29. Iacono G., Carroccio A., Cavataio F., Montalto G., Soresi M., BalsamoV.: Use of ass’ milk in multiple food allergy. J. Pediatr. Gastroenterol.Nutr., 1992; 14: 177-181
  Google Scholar
• 30. Ivanković A., Ramljak J., Štulina I., Antunac N., Bašić I., KelavaN., Konjačić M.: Characteristics of the lactation, chemical compositionand milk hygiene quality of the Littoral-Dinaric ass. Mljekarstvo,2009; 59: 107-113
  Google Scholar
• 31. Iwańczak F.: Profilaktyka alergii pokarmowej u noworodkówi niemowląt. Nowa Pediatria, 2002; 3: 115-118
  Google Scholar
• 32. Jasińska M., Skryplonek K.: Mleko klaczy, jego właściwości i wykorzystanie.Prz. Hod., 2013; 6: 22-24
  Google Scholar
• 33. Konuspayeva G., Faye B., Loiseau G., Levieux D.: Lactoferrinand immunoglobulin contents in camel’s milk (Camelus bactrianus,Camelus dromedarius, and hybrids) from Kazakhstan. J. Dairy Sci.,2007; 90: 38-46
  Google Scholar
• 34. Krełowska-Kułas M.: Alergie pokarmowe. Zesz. Nauk. AEK, 2006;705: 93-99
  Google Scholar
• 35. Król J., Brodziak A., Litwińczuk A.: Podstawowy skład chemicznyi zawartość wybranych białek serwatkowych w mleku krów różnychras i w serwatce podpuszczkowej. Zywn-Nauk. Technol. Ja.,2011; 4: 74-83
  Google Scholar
• 36. Król J., Litwińczuk Z., Brodziak A., Barłowska J.: Lactoferrin,lysozyme and immunoglobulin G content in milk of four breeds ofcows managed under intensive production system. Pol. J. Vet. Sci.,2010; 13: 357-361
  Google Scholar
• 37. Lara-Villoslada F., Olivares M., Xaus J.: The balance between caseinsand whey proteins in cow’s milk determines its allergenicity.J. Dairy Sci., 2005; 88: 1654-1660
  Google Scholar
• 38. Liu L.L., Yao H., Zhang X.L., Zhang H.L., Chao P.L., Tong M.L.,Liu G.L., Lin L.R., Fan-Liu, Zhang Z.Y., Yang T.C.: Characteristics ofpatients suffering from cow milk allergy. Int. Immunopharmacol.,2012; 14: 94-98
  Google Scholar
• 39. Majkowska-Wojciechowska B., Wardzyńska A., Łuczyńska M., KowalskiM.K., Makowska J., Kowalski M.L.: Nadwrażliwość na pokarmyw populacji dzieci szkolnych w Łodzi – wyniki badań ankietowychw projekcie „EuroPrevall”. Alerg. Astma Immun., 2009, 14: 35-44
  Google Scholar
• 40. Małaczyńska T.: Uczulenie na mleko krowie. Alergologia Współczesna,1999; 3: 9-13
  Google Scholar
• 41. Markiewicz-Kęszycka M., Wójtowski J., Kuczyńska B., Puppel K.,Czyżak-Runowska G., Bagnicka E., Strzałkowska N., Jóźwik A., KrzyżewskiJ.: Chemical composition and whey protein fraction of latelactation mares’ milk. Int. Dairy J., 2013; 31: 62-64
  Google Scholar
• 42. Marszałkowska J., Gutowska J., Samoliński B.: Częstość występowaniadodatnich testów skórnych na alergeny pokarmowe w specjalistycznejporadni alergologicznej. Alerg. Astma Immun., 2007;12: 160-164
  Google Scholar
• 43. Moatsou G., Moschopoulou E., Mollé D., Gagnaire V., KandarakisI., Léonil J.: Comparative study of the protein fraction of goat milkfrom the Indigenous Greek breed and from international breeds.Food Chem., 2008; 106: 509-520
  Google Scholar
• 44. Mona E.Y., Ragia O.M., Abeer A.K., Mosa T.E.: Biochemical effectsof fermented camel milk on diarrhea in rats. New York Sci.J., 2010; 3: 106-111
  Google Scholar
• 45. Monti G., Bertino E., Muratore M.C., Coscia A., Cresi F., SilvestroL., Fabris C., Fortunato D., Giuffrida M.G., Conti A.: Efficacy of donkey-’s milk in treating highly problematic cow’s milk allergic children: anin vivo and in vitro study. Pediatr. Allergy Immunol., 2007; 18: 258-264
  Google Scholar
• 46. Mullaicharam A.R.: A review on medicinal properties of camelmilk. World J. Pharm. Sci., 2014; 2: 237-242
  Google Scholar
• 47. Natale M., Bisson C., Monti G., Peltran A., Garoffo L.P., ValentiniS., Fabris C., Bertino E., Coscia A., Conti A.: Cow’s milk allergensidentification by two-dimensional immunoblotting and mass spectrometry.Mol. Nutr. Food Res., 2004; 48: 363-369
  Google Scholar
• 48. Nudda A., Feligini M., Battacone G., Macciotta N.P., Pulina G.:Effects of lactation stage, parity, β-lactoglobulin genotype and milkSCC on whey protein composition in Sarda dairy ewes. Ital. J. Anim.Sci., 2003; 2: 29-39
  Google Scholar
• 49. Nwaru B.I., Hickstein L., Panesar S.S., Muraro A., Werfel T., CardonaV., Dubois A.E., Halken S., Hoffmann-Sommergruber K., Poulsen L.K., Roberts G., Van Ree R., Vlieg-Boerstra B.J,, Sheikh A.: Theepidemiology of food allergy in Europe: a systematic review andmeta-analysis. Allergy, 2014; 69: 62-75
  Google Scholar
• 50. Orczyk-Pawiłowicz M., Wesołowska A.: Różnice w biochemicznymskładzie mleka matek wcześniaków i noworodków urodzonycho czasie – aspekt żywieniowy i terapeutyczny. Stand. Med., Pediatr.,2013; 10: 677-686
  Google Scholar
• 51. Pałgan K., Bartuzi Z.: Czynniki genetyczne i środowiskowe w rozwojualergii na pokarmy. Postępy. Hig. Med. Dosw., 2012; 66: 385-391
  Google Scholar
• 52. Park Y.W.: Hypo-allergenic and therapeutic significance of goatmilk. Small Ruminant Res., 1994; 14: 151-159
  Google Scholar
• 53. Park Y.W., Haenlein G.F.: Handbook of milk of non-bovine mammals.Blackwell Publishing, UK, 2006
  Google Scholar
• 54. Pavić V., Antunac N., Ivanković A., Havranek J.L.: Influence ofstage of lactation on chemical composition and physical propertiesof sheep milk. Czech J. Anim. Sci., 2002; 47: 80-84
  Google Scholar
• 55. Pawankar R., Canonica G.W., Holgate S.T., Lockey R.F., Blaiss M.S.(red.): White Book on Allergy: Update 2013. World Allergy Organization(WAO), United States of America, 2013
  Google Scholar
• 56. Pieszka M., Łuszczyński J., Szeptalin A.: Comparison of mare’smilk composition of different breeds. Nauka Przyr. Technol., 2011;5: 1-5
  Google Scholar
• 57. Polidori P., Vincenzetti S.: Protein profile characterization ofdonkey milk. W: Milk Protein, red.: Hurley W.L. In Tech – Open AccessPublisher, Rijeka 2012, 215-232
  Google Scholar
• 58. Polidori P., Vincenzetti S.: Use of donkey milk in children withcow’s milk protein allergy. Foods, 2013; 2: 151-159
  Google Scholar
• 59. Poth A.G, Deeth H.C., Alewood P.F., Holland J.W.: Analysis ofthe human casein phosphoproteome by 2-D electrophoresis andMALDI-TOF/TOF MS reveals new phosphoforms. J. Proteome Res.,2008; 7: 5017-5027
  Google Scholar
• 60. Raynal-Ljutovac K., Lagriffoul G., Paccard P., Guillet I., ChilliardY.: Composition of goat and sheep milk products: An update. SmallRuminant Res., 2008; 79: 57-72
  Google Scholar
• 61. Restani P., Ballabio C., Di Lorenzo C., Tripodi S., Fiocchi A.: Molecularaspects of milk allergens and their role in clinical events.Anal. Bioanal. Chem., 2009; 395: 47-56
  Google Scholar
• 62. Restani P., Gaiaschi A., Plebani A., Beretta B., Cavagni G., FiocchiA., Poiesi C., Velona T., Ugazio A.G., Galli C.L.: Cross-reactivitybetween milk proteins from different animal species. Clin. Exp. Allergy,1999; 29: 997-1004
  Google Scholar
• 63. Rozporządzenie Parlamentu Europejskiego i Rady (UE) Nr1169/2011 z dnia 25 października 2011 r. w sprawie przekazywaniakonsumentom informacji na temat żywności, zmiany rozporządzeńParlamentu Europejskiego i Rady (WE) nr 1924/2006 i (WE)nr 1925/2006 oraz uchylenia dyrektywy Komisji 87/250/EWG, dyrektywyRady 90/496/EWG, dyrektywy Komisji 1999/10/WE, dyrektywy2000/13/WE Parlamentu Europejskiego i Rady, dyrektywKomisji 2002/67/WE i 2008/5/WE oraz rozporządzenia Komisji (WE)nr 608/2004
  Google Scholar
• 64. Rudloff S., Kunz C.: Protein and nonprotein nitrogen componentsin human milk, bovine milk, and infant formula: quantitativeand qualitative aspects in infant nutrition. J. Pediatr. Gastroenterol.Nutr., 1997; 24: 328-344
  Google Scholar
• 65. Ruska D., Jonkus D.: Crude protein and non-protein nitrogencontent in dairy cow milk. Proc. Latv. Univ. Agr., 2014; 32: 36-40
  Google Scholar
• 66. Sacchi P., Chessa S., Budelli E., Bolla P., Ceriotti G., Soglia D., RaseroR., Cauvin E., Caroli A.: Casein haplotype structure in five Italian goat breeds. J. Dairy Sci., 2005; 88: 1561-1568
  Google Scholar
• 67. Salimei E., Fantuz F.: Equid milk for human consumption. Int.Dairy J., 2012; 24: 130-142
  Google Scholar
• 68. Salimei E., Fantuz F., Coppola R., Chiofalo B., Polidori P., VariscoG.: Composition and characteristics of ass’s milk. Anim. Res.,2004; 53: 67-78
  Google Scholar
• 69. Shamsia S.M.: Nutritional and therapeutic properties of cameland human milks. Int. J. Genet. Mol. Biol., 2009; 1: 52-58
  Google Scholar
• 70. Sharma S., Kumar P., Betzel C., Singh T.P.: Structure and functionof proteins involved in milk allergies. J. Chromatogr. B Biomed. Sci.Appl., 2001; 756: 183-187
  Google Scholar
• 71. Slačanac V., Božanić R., Hardi J., Szabó J.R., Lučan M., KrstanovićV.: Nutritional and therapeutic value of fermented caprine milk. Int.J. Dairy Technol., 2010; 63: 171-189
  Google Scholar
• 72. Socha J.: Żywienie w chorobach wieku dziecięcego. W: ŻywienieCzłowieka Zdrowego i Chorego t. 2, red.: Grzymisławski M., GawęckiJ., Wyd. PWN, Warszawa 2012, 158-172
  Google Scholar
• 73. Sorva R., Mäkinen-Kiljunen S., Juntunen-Backman K.:β-lactoglobulin secretion in human milk varies widely after cow’smilk ingestion in mothers of infants with cow’s milk allergy. J. Allergy.Clin. Immunol., 1994; 93: 787-792
  Google Scholar
• 74. Statistics Division. Food and Agriculture Organization of theUnited Nations – FAOSTAT. http://faostat.fao.org (21.07.2015)
  Google Scholar
• 75. Szwajkowska M., Wolanciuk A., Barłowska J., Król J., LitwińczukZ.: Bovine milk proteins as the source of bioactive peptides influencingthe consumers’ immune system – a review. Anim. Sci. Pap.Rep., 2011; 29: 269-280
  Google Scholar
• 76. Uniacke-Lowe T.: Studies on equine milk and comparative studieson equine and bovine milk systems. PhD Thesis, UniversityCollege Cork, Ireland, 2011, ss. 535
  Google Scholar
• 77. Uniacke-Lowe T., Huppertz T., Fox P.F.: Equine milk proteins:chemistry, structure and nutritional significance. Int. Dairy J., 2010;20: 609-629
  Google Scholar
• 78. Vincenzetti S., Polidori P., Fantuz F., Mariani P.L., CammertoniN., Vita A., Polidori F.: Donkey’s milk caseins characterization. Ital.J. Anim. Sci., 2005; 4: 427-429
  Google Scholar
• 79. Vincenzetti S., Polidori P., Mariani P., Cammertoni N., FantuzF., Vita A.: Donkey’s milk protein fractions characterization. FoodChem., 2008; 106: 640-649
  Google Scholar
• 80. Wal J.M.: Structure and function of milk allergens. Allergy, 2001;56: 35-38
  Google Scholar
• 81. Wilson J.: Milk intolerance: lactose intolerance and cow’s milkprotein allergy. Newborn. Infant. Nurs. Rev., 2005; 5: 203-207
  Google Scholar
• 82. Wróblewska B., Jedrychowski L.: Wpływ modyfikacji technologicznychna zmianę właściwości immunoreaktywnych białek mlekakrowiego. Alerg. Astma Immun., 2003; 8: 157-164
  Google Scholar
• 83. Žan M., Stibilj V., Rogelj I.: Milk fatty acid composition of goatsgrazing on alpine pasture. Small Ruminant Res. 2006; 64: 45-52
  Google Scholar
• 84. Zawadzka-Krajewska A.: Preparaty mlekozastępcze stosowanew leczeniu alergii pokarmowej u niemowląt. Alergia, 2006, 2: 31-33
  Google Scholar
• 85. Zhang R., Mustafa A.F., Zhao X.: Effects of flaxseed supplementationto lactating ewes on milk composition, cheese yield, and fattyacid composition of milk and cheese. Small Ruminant Res., 2006;63: 233-24
  Google Scholar

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