M Stajszczyk 1 , J Gmiński
1. Katedra i Zakład Biochemii i Chemii Slaskiej Akademii Medycznej w Katowicach.
Published:
GICID: 01.3001.0000.3077
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1996; 50 (2)
Abstract
The activation of the renin-angiotensin system has been proposed as a very important step in the pathogenesis of atherosclerosis. Accordingly, ACE-inhibitors and angiotensin II receptors antagonists showed their ability to reduce the atherosclerotic process in animals. Inhibition of renin-angiotensin system reduces the development of atherosclerotic lesion either in cholesterol-fed animals and in animals after vascular injury. The precise mechanism for this action may depend on the inhibition of other than hypertensive property of angiotensin II.