Abstract

Recent decades have been devoted to the intense search for the response to questions related to the impact of radiation on the human body. Due to the growing fashion for a healthy lifestyle, increasing numbers of works about the alleged dangers of electromagnetic waves and diseases that they cause appeared. However, the discoveries of 20th century, and knowledge of the properties of electromagnetic radiation have allowed to broaden the horizons of the use of artificial sources of radiation in many fields of science and especially in medicine. The aim of this paper is to show that although excessive radiation or high doses are dangerous to the human body, its careful and controlled use, does not pose a threat, and it is often necessary in therapy. The possibility of using ionizing radiation in radiotherapy, isotope diagnostics or medical imaging, and non-ionizing radiation in the treatment for dermatological disorders and cancers will be presented. The unique properties of synchrotron radiation result in using it on a large scale in the diagnosis of pathological states by imaging methods.

References

• 1. Acierno M.J., Mitchell M.A., Roundtree M.K., Zachariah T.T.: Effectsof ultraviolet radiation on 25-hydroxyvitamin D3 synthesis inred-eared slider turtles (Trachemys scripta elegans). Am. J. Vet. Res.,2006; 67: 2046-2049
  Google Scholar
• 2. Agostinis P., Berg K., Cengel K.A., Foster T.H., Girotti A.W., GollnickS.O., Hahn S.M., Hamblin M.R., Juzeniene A., Kessel D., Korbelik M.,Moan J., Mroz P., Nowis D., Piette J., Wilson B.C, Golab J.: Photodynamictherapy of cancer: an update. CA Cancer J. Clin., 2011; 61: 250-281
  Google Scholar
• 3. Alharbi A.A., Azzam A., McCleskey M., Roeder B., Spiridon A.,Simmons E., Goldberg W.Z., Banu A., Trache L., Tribble R.E.: Medicalradioisotopes production: a comprehensive cross-section studyfor the production of Mo and Tc radioisotopes via proton inducednuclear reactions on natMo. W: Radioisotopes – Applications in BioMedicalScience, red. N. Singh, In Tech, 2011
  Google Scholar
• 4. Ayaru L., Bown S.G., Pereira S.P.: Photodynamic therapy for pancreaticand biliary tract carcinoma. Int. J. Gastrointest. Cancer, 2005;35: 1-13
  Google Scholar
• 5. Baker M.J., Gazi E., Brown M.D., Shanks J.H., Gardner P., ClarkeN.W.: FTIR-based spectroscopic analysis in the identification of clinicallyaggressive prostate cancer. Br. J. Cancer, 2008; 99: 1859-1866
  Google Scholar
• 6. Barrett A., Dobbs J., Morris S., Roques T.: Radiobiology and treatmentplanning. W: Partical Radiotherapy Planning, Macmillan PublishingSolutions, Italy 2009
  Google Scholar
• 7. Bernhard E.J., Maity A., Muschel R.J., McKenna W.G.: Effects ofionizing radiation on cell cycle progression. Radiat. Environ. Biophys.,1995; 34: 79-83
  Google Scholar
• 8. Berroud A., Le Roy A., Voisin P.: Membrane oxidative damage inducedby ionizing radiation detected by fluorescence polarization.Radiat. Environ. Biophys., 1996; 35: 289-295
  Google Scholar
• 9. Berti V., Osorio R.S., Mosconi L., Li Y., De Santi S., de Leon M.J.:Early detection of Alzheimer’s disease with PET imaging. Neurodegener.Dis., 2010; 7: 131-135
  Google Scholar
• 10. Bruening W., Uhl S., Fontanarosa J., Reston J., Treadwell J.,Schoelles K.: Noninvasive diagnostic tests for breast abnormalities:update of a 2006 review. Comp. Effectiv. Rev., 2012; 47: 1-73
  Google Scholar
• 11. Choi J., Raghavan M.: Diagnostic imaging and image-guidedtherapy of skeletal metastases. Cancer Control, 2012; 19: 102-112
  Google Scholar
• 12. Ciernik I.F., Dizendorf E., Baumert B.G., Reiner B., Burger C., DavisJ.B., Lütolf U.M., Steinert H.C., Von Schulthess G.K.: Radiation treatmentplanning with an integrated positron emission and computertomography (PET/CT): a feasibility study. Int. J. Radiat. Oncol. Biol.Phys., 2003; 57: 853-863
  Google Scholar
• 13. Crinnion W.J.: Sauna as a valuable clinical tool for cardiovascular,autoimmune, toxicant-induced and other chronic health problems.Altern. Med. Rev., 2011; 16: 215-225
  Google Scholar
• 14. Dauter Z.: Efficient use of synchrotron radiation for macromoleculardiffraction data collection. Prog. Biophys. Mol. Biol., 2005;89: 153-172
  Google Scholar
• 15. Dawson L.A., Ménard C.: Imaging in radiation oncology: a perspective.Oncologist, 2010; 15: 338-349
  Google Scholar
• 16. Dougherty T.J., Gomer C.J., Henderson B.W., Jori G., Kessel D.,Korbelik M., Moan J., Peng Q.: Photodynamic therapy. J. Natl. CancerInst., 1998; 90: 889-905
  Google Scholar
• 17. Engelsen O.: The relationship between ultraviolet radiation exposureand vitamin D status. Nutrients, 2010; 2: 482-495
  Google Scholar
• 18. Ganswindt U., Belka C.: Radiotherapy in prostate cancer. UrologeA, 2008; 47: 1245-1254
  Google Scholar
• 19. Girard P.M., Francesconi S., Pozzebon M., Graindorge D., RochetteP., Drouin R., Sage E.: UVA-induced damage to DNA and proteins:direct versus indirect photochemical processes. J. Phys.: Conf. Ser.,2011; 261: 012002
  Google Scholar
• 20. Häder D.P., Kumar H.D., Smith R.C., Worrest R.C.: Effects of solarUV radiation on aquatic ecosystems and interactions with climatechange. Photochem. Photobiol. Sci., 2007; 6: 267-285
  Google Scholar
• 21. Häder D.P., Sinha R.P.: Solar ultraviolet radiation-induced DNAdamage in aquatic organisms: potential environmental impact. Mutat.Res., 2005; 571: 221-233
  Google Scholar
• 22. Hibma J.C.: Dietary vitamin D3 and UV-B exposure effects ongreen iguana growth rate: is full-spectrum lighting necessary? Bull.Chicago Herp. Soc. 2004; 398: 145-150
  Google Scholar
• 23. Hong-Tae K., Ki-Hong K., Gi-Hwan Ch., SangHoon J., Sung-HwanP., Bong-Il K., Kazuyuki H., Masami A., Jong-Ki K.: Photodynamicsynchrotron X-ray therapy in glioma cell using superparamagneticiron nanoparticle. Proc. SPIE, 2009; 7380: 1-10
  Google Scholar
• 24. Iliakis G., Wang Y., Guan J., Wang H.: DNA damage checkpointcontrol in cells exposed to ionizing radiation. Oncogene, 2003; 22:5834-5847
  Google Scholar
• 25. Kalender W.A.: Computed tomography: fundamentals, systemtechnology, image quality, applications. Publicis Publishing, Erlangen.2011
  Google Scholar
• 26. Kamrava S.K., Behtaj M., Ghavami Y., Shahabi S., Jalessi M., AfsharE.E., Maleki S.: Evaluation of diagnostic values of photodynamicdiagnosis in identifying the dermal and mucosal squamous cell carcinoma.Photodiagnosis Photodyn. Ther., 2012; 9: 293-298
  Google Scholar
• 27. Karam P.A.: Radioactivity. Chelsea House Publishers, New York2009
  Google Scholar
• 28. Keller S.M. Photodynamic therapy. Biology and clinical application.Chest Surg. Clin. N. Am., 1995; 5: 121–137
  Google Scholar
• 29. Kempner E.S.: Damage to proteins due to the direct action ofionizing radiation. Q. Rev. Biophys., 1993; 26: 27-48
  Google Scholar
• 30. Kisiel A.: Synchrotron jako narzędzie: zastosowania promieniowaniasynchrotronowego w spektroskopii ciała stałego. SynchrotronRadiat. Natural Sci., 2006; 5: 145-167
  Google Scholar
• 31. Laissue J.A., Blattmann H., Wagner H.P., Grotzer M.A., SlatkinD.N.: Prospects for microbeam radiation therapy of brain tumoursin children to reduce neurological sequelae. Dev. Med. Child Neurol.,2007; 49: 577-581
  Google Scholar
• 32. Latanowicz L., Latosińska J.: Promieniowanie UV a środowisko.Wydawnictwo Naukowe PWN, Warszawa, 2011
  Google Scholar
• 33. Lin C.C., Chang C.F., Lai M.Y., Chen T.W., Lee P.C., Yang W.C.: Farinfraredtherapy: a novel treatment to improve access blood flowand unassisted patency of arteriovenous fistula in hemodialysispatients, J. Am. Soc. Nephrol., 2007; 18: 985-992
  Google Scholar
• 34. MacDonald A., Burden A.D.: Psoriasis: advances in pathophysiologyand management. Postgrad. Med. J., 2007; 83: 690-697
  Google Scholar
• 35. Newman T.B., Vittinghoff E., McCulloch C.E.: Efficacy of phototherapyfor newborns with hyperbilirubinemia: a cautionary exampleof an instrumental variable analysis. Med. Decis. Making,2012; 32: 83-92
  Google Scholar
• 36. Olds W.J., McKinley A.R., Moore M.R., Kimlin M.G.: In vitro modelof vitamin D3 (cholecalciferol) synthesis by UV radiation: doseresponserelationships, J. Photochem. Photobiol. B, 2008; 93: 88-93
  Google Scholar
• 37. Paul S.A., Stoeckli S.J., von Schulthess G.K., Goerres G.W.: FDGPET and PET/CT for the detection of the primary tumour in patientswith cervical non-squamous cell carcinoma metastasis of anunknown primary. Eur. Arch. Otorhinolaryngol., 2007; 264: 189-195
  Google Scholar
• 38. Pełka J.B.: Synchrotron radiation in biology and medicine. ActaPhys. Pol., 2008; 114: 309-329
  Google Scholar
• 39. Polgár C., Major T.: Current status and perspectives of brachytherapyfor breast cancer. Int. J. Clin. Oncol., 2009; 14: 7-24
  Google Scholar
• 40. Prezado Y., Adam J.F., Berkvens P., Martinez-Rovira I., Fois G.,Thengumpallil S., Edouard M., Vautrin M., Deman P., Bräuer-KrischE., Renier M., Elleaume H., Esteve F., Bravin A.: Synchrotron radiationtherapy from a medical physics point of view, AIP Conf. Proc.,2010; 1266: 101
  Google Scholar
• 41. Rajpara A.N., O’Neill J.L., Nolan B.V., Yentzer B.A., Feldman S.R.:Review of home phototherapy. Dermatol. Online J., 2010; 16: 2
  Google Scholar
• 42. Rastogi R.P., Richa, Kumar A., Tyagi M.B., Sinha R.P.: Molecularmechanisms of ultraviolet radiation-induced DNA damage and repair.J. Nucleic Acids, 2010; 2010: 592980
  Google Scholar
• 43. Sachs R.K., Chen P.L., Hahnfeldt P.J., Hlatky L.R.: DNA damagecaused by ionizing radiation. Math. Biosci., 1992; 112: 271-303
  Google Scholar
• 44. Schootman M., Jeffe D.B., Gillanders W.E., Yan Y., Aft R.: The effectsof radiotherapy for the treatment of contralateral breast cancer.Breast Cancer Res. Treat., 2007; 103: 77-83
  Google Scholar
• 45. Sibata C.H., Colussi V.C., Oleinick N.L., Kinsella T.J.: Photodynamictherapy: a new concept in medical treatment. Braz. J. Med.Biol. Res., 2000; 33: 869-880
  Google Scholar
• 46. Sourtti P., Thomlinson W.: Medical applications of synchrotronradiation. Phys. Med. Biol., 2003; 48: R1-R35
  Google Scholar
• 47. Speiser B.L.: Brachytherapy for lung cancer. Radiat. Oncol. 2000;55: 19
  Google Scholar
• 48. Spotheim-Maurizot M., Davídková M.: Radiation damage to DNAproteincomplexes. J. Phys.: Conf. Ser., 2011; 261: 012010
  Google Scholar
• 49. Sprung C.N., Cholewa M., Usami N., Kobayashi K., Crosbie J.C.:DNA damage and repair kinetics after microbeam radiation therapyemulation in living cells using monoenergetic synchrotron X-raymicrobeams. J. Synchrotron Radiat., 2011; 18: 630-636
  Google Scholar
• 50. Stylli S.S., Kaye A.H.: Photodynamic therapy of cerebral glioma –a review. Part II – clinical studies. J. Clin. Neurosci., 2006, 13: 709-717
  Google Scholar
• 51. Su Y., Meador J.A., Geard C.R., Balajee A.S.: Analysis of ionizingradiation-induced DNA damage and repair in three-dimensional humanskin model system. Exp. Dermatol., 2010; 19: e16-e22
  Google Scholar
• 52. Suntharalingam N., Podgorsak E.B., Tolli H.: Brachytherapy: physicaland clinical aspects W: Radiation oncology physics: A handbookfor teachers and students, red.: E.B. Podgorsak, IAEA, Austria, 2005
  Google Scholar
• 53. Sutherland B.M.: UV effects in “the real world”: problems ofUV dosimetry in complex organisms. J. Photochem. Photobiol. B,1997; 40: 8-13
  Google Scholar
• 54. Tatsumi M., Cohade C., Mourtzikos K.A., Fishman E.K., Wahl R.L.:Initial experience with FDG-PET/CT in the evaluation of breast cancer.Eur. J. Nucl. Med. Mol. Imaging, 2006; 33: 254-262
  Google Scholar
• 55. Vincent W.F., Neale P.J.: Mechanisms of UV damage to aquaticorganisms. W: The effects of UV Radiation in the Marine Environment.red.: S. de Mora, S. Demers, M. Vernet, Cambridge UniversityPress, Cambridge, 2000, 149-176
  Google Scholar
• 56. Xiong T., Chen D., Duan Z., Qu Y., Mu D.: Clofibrate for unconjugatedhyperbilirubinemia in neonates: a systematic review. IndianPediatr., 2012; 49: 35-41
  Google Scholar
• 57. Zhang Y., Zhao C., Liu H., Hou H., Zhang H.: Multiple metastasislikebone lesions in scintigraphic imaging. J. Biomed. Biotechnol.,2012; 2012: 957364
  Google Scholar

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