[Beta-3 adrenergic receptor–structure and role in obesity and metabolic disorders]

J Wiejak ¹ , E Wyroba

1. Zakład Biologii Komórki, Instytut Biologii Doświadczalnej im. M. NenckiegoPAN w Warszawie.

Published:

GICID: 01.3001.0000.3245

Available language versions: en pl

Issue: Postepy Hig Med Dosw 1999; 53 (5)

Abstract

Structure and essential motifs of beta 3-adrenergic receptor (known previously as atypical beta-AR), which plays a central role in regulation of lipid metabolism have been described. Obesity results from an imbalance between caloric intake and energy expenditure. The consequence of catecholamine activation of beta 3-AR is increased mobilization of fatty acids from triglyceride stores (lipolysis) in brown and white adipose tissue as well as increased fatty acid beta-oxidation and heat-production via UCP-1 (thermogenesis) in brown adipose tissue. A pharmacokinetic effects of beta 3-agonists and putative involvement of Trp/Arg mutation in beta 3-AR gene in obesity and another metabolic disorders have been discussed.