[Cross-talk between signal transduction pathways in the cell– the role of G proteins in these processes]

J Barańska ¹

1. Zakład Neurobiologii Molekularnej i Komórkowej Instytutu Biologii DoświadczalnejPAN im. M. Nenckiego w Warszawie.

Published:

GICID: 01.3001.0000.3205

Available language versions: en pl

Issue: Postepy Hig Med Dosw 1999; 53 (2)

Abstract

Family of heterotrimeric G proteins plays an essential role in transducing signals across the plasma membrane in animal cells. Members of G protein family have been grouped into four subtypes: Gs, Gi, Gq and G12. A cross-talk between Gi- and Gq-; Gs- and Gi-; and Gs- and Gi-coupled receptors are presented. Interactions between G protein coupled receptors and receptor tyrosine kinases and between G12 protein and the small molecular weight guanosine trisphosphate protein Rho are also described.