REVIEW ARTICLE
Defensins in humans and animals
Jakub Deptuła 1 , Beata Tokarz-Deptuła 2 , Wiesław Deptuła 31. Zakład Genetyki i Patomorfologii, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim, Pomorski Uniwersytet Medyczny w Szczecinie,
2. Katedra Immunologii, Wydział Biologii, Uniwersytet Szczeciński, Szczecin,
3. Centrum Weterynarii, Uniwersytet Mikołaja Kopernika, Toruń,
Published: 2019-03-18
DOI: 10.5604/01.3001.0013.1135
GICID: 01.3001.0013.1135
Available language versions: en pl
Issue: Postepy Hig Med Dosw 2019; 73 : 152-158
Abstract
Defensins are immune peptides – HDP (Host Defense Peptides) that present high activity against viruses, bacteria and fungi in mammals, including humans. They are an important element of natural resistance in macroorganisms, when microorganisms couldn’t developed this resistance during the evolution. Defensins in vertebrate macroorganisms, have direct and indirect impact on germs, including stimulating the synthesis of immune substances such as cytokines, chemokines and growth factors.