REVIEW ARTICLE

Influence of abnormalities of TP53 and ATM genes for course of B-cell chronic lymphocytic leukemia

Zofia Rupniewska , Ewa Wąsik-Szczepanek

Published: 2001-11-15

GICID: 01.3001.0000.3476

Available language versions: en

Issue: Postepy Hig Med Dosw 2001; 55 (6)

Abstract

Uncontrolled cell proliferation is the hallmark of cancer, and tumour cells have typically acquired damage to genes that directly regulate their cell cycles. Genes that link checkpoint controls to cancer and other related genetic disease include the TP53 and ATM genes. The abnormalities of these genes are clearly associated with particular forms of the B-cell chronic lymphocytic leukemia and poor prognosis.