A Szutowicz 1 , M Tomaszewicz , A Jankowska , B Madziar , H Bielarczyk
1. Katedra i Zakład Biochemii Klinicznej Akademii Medycznej w Gdańsku.
Published:
GICID: 01.3001.0000.3216
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1999; 53 (2)
Abstract
Preferential loss of cholinergic neurons in course of several encephalopathies may result from the fact that they utilize acetyl-CoA not only for energy production, but also for acetylcholine synthesis. Changes in activities of acetyl-CoA metabolizing enzymes and shifts in acetyl-CoA compartmentalization, found in different animal models of brain pathologies and in human post mortem brain, are discussed in therms of their impact on cholinergic system integrity.