[New chemical method for synthesis of O-linked glycopeptides]

R L Polt 1 , L Szabo J Ramza

1. Department of Chemistry, University of Arizona, Tucson, USA.

Published:

GICID: 01.3001.0000.3100

Available language versions: en pl

Issue: Postepy Hig Med Dosw 1996; 50 (5)

Abstract

The diphenylketone Shiff-base appeared to be a very good protection from amino groups of serine and threonine for glycosylation reaction. O-Glycosides of these amino acids with different monosaccharides, aminosugars and deoxysugars were obtained with excellent yield and very high stereoselectivity. Products of glycosylation reactions were used as building blocks for solid phase glycopeptide synthesis.

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