Abstract

In the article new aspects of the ‘male factor’ and its role in early stages of pregnancy are described. Among others, genetic and immunogenetic (KIR/KAR, HLA) factors are underlined as well as immunological ones (e.g. microchimerism). A significant part of this review is dedicated to infectious agents and semen inflammation as well as to the TORCH syndrome and chlamydiosis, concentrating on the male part, in which there are a lot of unclarified consequences. The problem of somatic diseases and general homeostasis of the male and its influence on pregnancy with particular emphasis on previous cryptorchidism is also discussed. The role of sperm DNA integrity in the fertilization process as well as genetic polymorphisms on the male side is emphasised. Particularly, molecular aspects of HLA-G and HLA-C in developmental biology are raised. There is a discussion of the individual approach to assisted reproductive techniques, which cannot be treated as a panacea for infertility treatment, particularly considering early stages of embryonal and fetal development.

References

• 1. Abdulmedzhidova A.G., Kurilo L.F., Shileiko L.V., Makarova N.P.,Klimova R.R., Kushch A.A.: Asymptomatic genital HSV infection andmale infertility. Urologija, 2007; 3: 56-59
  Google Scholar
• 2. Amaral S., Oliveira P.J., Ramalho-Santos J.: Diabetes and the impairmentof reproductive function: possible role of mitochondria andreactive oxygen species. Curr. Diabetes Rev., 2008; 4: 46-54
  Google Scholar
• 3. Astin M., Scott J.R., Worley R.J.: Pre-eclampsia/eclampsia: a fatalfather factor. Lancet, 1981; 2: 533
  Google Scholar
• 4. Bocharowa E.N., Bragina E.E., Gusak J.K.: Geneticheskoe inficirowaniespermatozoidow pri neudachah ispol’zowanija reproduktiwnychtehnologij i spontannom prierywanii beremennosti.Urologiya, 2007; 3: 59-62
  Google Scholar
• 5. Bozhedomov V.A., Gromenko D.S., Ushakova I.V., Toroptseva M.V.,Galimov S.N., Alexandrova L.A., Teodorovich O.V., Sukhikh G.T.: Oxidativestress of spermatozoa in pathogenesis of male infertility.Urologija, 2009; 2: 51-56
  Google Scholar
• 6. Combelles C.M., Morozumi K., Yanagimachi R., Zhu L., Fox J.H.,Racowsky C.: Diagnosing cellular defects in an unexplained case oftotal fertilization failure. Hum. Reprod., 2010; 25: 1666-1671
  Google Scholar
• 7. De Geyter C., Boehler B., Reiter-Theil S.: Differences and similaritiesin the attitudes of paediatricians, gynaecologists and experiencedparents to criteria delineating potential risks for the welfareof children to be conceived with assisted reproduction. Swiss Med.Wkly., 2010; 140: 13064
  Google Scholar
• 8. De Luca Brunori I., Battini L., Simonelli M., Clemente F., BrunoriE., Mariotti M.L., Genazzani A.R.: Increased HLA-DR homozygosityassociated with pre-eclampsia. Hum. Reprod., 2000; 15: 1807-1812
  Google Scholar
• 9. Dekker G., Robillard P.Y., Roberts C.: The etiology of preeclampsia:the role of the father. J. Reprod. Immunol., 2011; 89: 126-132
  Google Scholar
• 10. Eley A.: How to detect Chlamydia trachomatis in males? J. Androl.,2011; 32: 15-22
  Google Scholar
• 11. Eley A., Pacey A.A.: The value of testing semen for Chlamydia trachomatisin men of infertile couples. Int. J. Androl., 2011; 34: 391-401
  Google Scholar
• 12. ESHRE Capri Workshop Group.: Genetic aspects of female reproduction.Hum. Reprod. Update, 2008; 14: 293-307
  Google Scholar
• 13. Fatima P., Debnath B.C., Hossain M.M., Rahman D., Banu J., BegumS.A., Rahman M.W.: Relationship of blood and semen lead levelwith semen parameter. Mymensingh Med. J., 2010; 19: 405-414
  Google Scholar
• 14. French A.E., Koren G., Motherisk Team: Effect of methotrexateon male fertility. Can. Fam. Physician., 2003; 49: 577-578
  Google Scholar
• 15. Freour T., Delvigne A., Barrière P.: Evaluation of the male ofthe infertile couple. J. Gynecol. Obstet. Biol. Reprod., 2010; 39 (8Suppl. 2): S45-S52
  Google Scholar
• 16. Gorpinczenko I.I., Gurzhenko J.N., Klimenko P.M., SpiridonenkoW.W.: Prakticheskij opyt kompleksnogo lecheniya bol’nykh ekskretorno-toksicheskimbesplodiem. Nowosti Mediciny i Farmacii,2010; 18: 10-12
  Google Scholar
• 17. Günyeli I., Abike F., Dünder I., Aslan C., Tapısız O.L., TemizkanO., Payaslı A., Erdemoğlu E.: Chlamydia, Mycoplasma and Ureaplasmainfections in infertile couples and effects of these infections onfertility. Arch. Gynecol. Obstet., 2011; 283: 379-385
  Google Scholar
• 18. Hanna C.W., Bretherick K.L., Liu C.C., Stephenson M.D., RobinsonW.P.: Genetic variation within the hypothalamus-pituitary-ovarianaxis in women with recurrent miscarriage. Hum. Reprod., 2010; 25:2664-2671
  Google Scholar
• 19. Janssen N.M., Genta M.S.: The effects of immunosuppressive andanti-inflammatory medications on fertility, pregnancy, and lactation.Arch. Intern. Med., 2000; 160: 610-619
  Google Scholar
• 20. Kalinina S.N., Tiktinskij O.L.: Lechenie hronicheskogo prostatita,obeslowlennogo hlamidijnoj i ureaplazmiennoj infekciej i oslozhnennogomyzhskim besplodiem. Urologija, 2010, 3: 52-57
  Google Scholar
• 21. Keymolen K., Staessen C., Verpoest W., Michiels A., Bonduelle M.,Haentjens P., Vanderelst J., Liebaers I.: A proposal for reproductivecounselling in carriers of Robertsonian translocations: 10 years ofexperience with preimplantation genetic diagnosis. Hum. Reprod.,2009; 24: 2365-2371
  Google Scholar
• 22. Kilic S., Yukse B., Tasdemir N., Dogan M., Ozdemir E., YesilyurtA., Keskin I.: Assisted reproductive treatment applicationsin men with normal phenotype but 45,X/46,XY mosaic karyotype:clinical and genetic perspectives. Taiwan. J. Obstet. Gynecol.,2010; 49: 199-202
  Google Scholar
• 23. Kirpatovskij I.D., Pokruchin N.A.: Transplantation of hormone–producting cells into the testicular paravasal fat hole in secretoryinfertility and gonadal hypoplasia. Urologija, 2008, 4: 43-46
  Google Scholar
• 24. Kurpisz M., Fraczek M., Piasecka M., Jedrzejczak P.: Oxidativestress, innate immunity and sperm quality. J. Reprod. Immunol.,2011; 90: 140
  Google Scholar
• 25. Leushuis E., van der Steeg J.W., Steures P., Repping S., SchölsW., van der Veen F., Mol B.W., Hompes P.G.: Immunoglobulin G antispermantibodies and prediction of spontaneous pregnancy. Fertil.Steril., 2009; 92: 1659-1665
  Google Scholar
• 26. Matzuk M.M., Lamb D.J.: The biology of infertility: researchadvances and clinical challenges. Nat. Med., 2008; 14: 1197-1213
  Google Scholar
• 27. Merhi Z.O., Pal L.: Gender “tailored” conceptions: should theoption of embryo gender selection be available to infertile couplesundergoing assisted reproductive technology? J. Med. Ethics, 2008;34: 590-593
  Google Scholar
• 28. Meseguer M., Santiso R., Garrido N., García-Herrero S., RemohíJ., Fernandez J.L.: Effect of sperm DNA fragmentation on pregnancyoutcome depends on oocyte quality. Fertil. Steril., 2011; 95: 124-128
  Google Scholar
• 29. Moskowitz S.M., Chmiel J.F., Sternen D.L., Cheng E., Cutting G.R.:CFTR-related disorders. W: GeneReviews™ [Internet]. Red.: PagonR.A., Adam M.P., Ardinger H.H., Wallace S.E., Amemiya A., Bean L.J.H.,Bird T.D., Dolan C.R., Fong C.T., Smith R.J.H., Stephens K.; Seattle(WA): University of Washington, Seattle 2001, 1993-2013
  Google Scholar
• 30. Neimark A.I., Aliev R.T., Nozdrachev N.A., Krainichenko S.V.,Elchaninova S.A., Zolovkina A.G., Popovtseva A.V., Bespalova O.V.,Lyashenko L.A.: Defects in spermatogenesis and their correction inpatients with chronic abacterial prostatitis. Urologija, 2008; 44: 46-50
  Google Scholar
• 31. Nielsen H.S., Steffensen R., van Halteren A.G., Spiering E., MiklosD., Claas F., Goulmy E., Christiansen O.B.: Anti H-Y immunity in secondaryrecurrent miscarriage – immunogenetic and immunologicevidence. J. Reprod. Immunol., 2011; 90: 142-143
  Google Scholar
• 32. Oger P., Nicollet B., Wainer B., de Crécy M.A.: Informations forthe infertile couple. J. Gynecol. Obstet. Biol. Reprod., 2010; 39 (8Suppl. 2): S100-S112
  Google Scholar
• 33. Pisipati S., Pearcy R.: The role of urological surgery in male infertility.Hum. Fertil., 2010; 13: 233-241
  Google Scholar
• 34. Reinblatt S.L., Buckett W.: In vitro maturation for patients withpolycystic ovary syndrome. Semin. Reprod. Med., 2008; 26: 121-126
  Google Scholar
• 35. Revonta M., Raitanen J., Sihvo S., Koponen P., Klemetti R., MännistöS., Luoto R.: Health and life style among infertile men and women.Sex. Reprod. Healthc., 2010; 1: 91-98
  Google Scholar
• 36. Saxena P., Misro M.M., Chaki S.P., Chopra K., Roy S., Nandan D.:Is abnormal sperm function an indicator among couples with recurrentpregnancy loss? Fertil. Steril., 2008; 90: 1854-1858
  Google Scholar
• 37. Szakina I.A., Pilipienko M.A., Poltoraka E.A., Liubawina A.E.:Sindrom poteri ploda. Nowosti, 2010; 16: 20-21
  Google Scholar
• 38. Tiboni G.M., Verna I., Giampietro F., Leonzio E., ImpicciatoreG.G.: Cytogenetic findings and reproductive outcome of infertilecouples referred to an assisted reproduction program. Gynecol. Endocrinol.,2011; 27: 669-674
  Google Scholar
• 39. Van Halteren A.G.: Tolerance and sensitization to minor histocompatibilityantigens in mother-offsprings pairs. J. Reprod.Immunol., 2011; 90: 132
  Google Scholar
• 40. Wettasinghe T.K., Jayasekara R.W., Dissanayake V.H.: Y chromosomemicrodeletions are not associated with spontaneous recurrentpregnancy loss in a Sinhalese population in Sri Lanka. Hum. Reprod.,2010; 25: 3152-3156
  Google Scholar
• 41. Wiser A., Raviv G., Weissenberg R., Elizur S.E., Levron J., MachtingerR., Madgar I.: Does age at orchidopexy impact on the results of testicularsperm extraction? Reprod. Biomed. Online, 2009; 19: 778-783
  Google Scholar
• 42. Zorn B., Ihan A., Kopitar A.N., Kolbezen M., Sesek-Briski A.,Meden-Vrtovec H.: Changes in sperm apoptotic markers as relatedto seminal leukocytes and elastase. Reprod. Biomed. Online, 2010;21: 84-92
  Google Scholar

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