Dorota Butkiewicz , Marek Rusin , Małgorzata Pawlas , Małgorzata Czarny , Mieczysław Chorazy
Published: 2002-07-15
GICID: 01.3001.0000.3515
Available language versions: en
Issue: Postepy Hig Med Dosw 2002; 56 (4)
Abstract
DNA damage repair, responsible for maintaining the genome integrity, plays a central role in cancer biology. Individual DNA repair capacity is genetically determined. Inherited defect in nucleotide excision repair (NER) genes leads to three distinct and extremely rare disorders: xeroderma pigmentosum, associated with high risk of skin cancer, Cockayne syndrome, and trichothiodystrophy. The recently identified common polymorphism in several NER genes may also influence a risk of cancer in general population. The review presents current knowledge about a role of genetic variation of NER genes in cancer predisposition.