Abstract

Diabetes mellitus is a metabolic disease that manifest itself hyperglycemia It is estimated that about 422 million people worldwide are affected by this disease. Great hopes in the prevention and support of pharmacological treatment of diabetes are associated with a new scientific discipline, which is nutrigenomics. Lowering the reports in the field of physiology, bromatology, genomics, proteomics, biochemistry or epigenetics, this field searches for and explains the interactions of genes with food components at the molecular level. The article presents the most important information on the bioactive effects of food (flavonoids, amino acids, vitamins, fatty acids) on the expression of genes connected with secretion/action of insulin and the metabolism of the glucose in the body. The article discusses the functions of genes that work on the pathogenesis of diabetes development, and presents experimental models in empirical research. In addition, it article presents the importance of epigenetic factor in the development of type 2 diabetes mellitus, as well as basic informations in the field of its diagnosis and differentiation.

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