Abstract

Paraneoplastic syndromes, which are discussed in this paper, are a heterogeneous group of disorders associated with cancer, but not directly caused by the physical effects of the primary tumor or its metastases. May precede the appearance of the malignant process, occur simultaneously or disclose in the course of cancer. Paraneoplastic syndromes may be caused directly by toxins produced by tumor cells, occur in the course of hypersensitivity reactions, or be the result of release of intracellular antigens. Due to the often similar systemic symptoms it is very important to evaluate the association of rheumatic diseases and cancer. Most paraneoplastic rheumatologic syndroms are difficult distinguishable from idiopathic rheumatologic disorders. The most common paraneoplastic syndromes include rheumatoid arthritis (RA)-like syndrome arthritis, inflammatory myopathies, hypertrophic osteoarthropathy, vasculitis and Raynaud’s phenomenon.

References

• 1. Abu-Shakra M., Buskila D., Ehrenfeld M., Conrad K., ShoenfeldY.: Cancer and autoimmunity: autoimmune and rheumaticfeatures in patients with malignancies. Ann. Rheum. Dis., 2001;60: 433-441
  Google Scholar
• 2. Adamus G.: Autoantibody-induced apoptosis as a possible mechanismof autoimmune retinopathy. Autoimmun. Rev., 2003; 2: 63-68
  Google Scholar
• 3. Airo’ P., Ceribelli A., Cavazzana I., Taraborelli M., Zingarelli S., FranceschiniF.: Malignancies in Italian patients with systemic sclerosis positivefor anti-RNA polymerase III antibodies. J. Rheumatol., 2011; 38:1329-1334
  Google Scholar
• 4. Alhadad A., Wollmer P., Svensson A., Eriksson K.F.: Erythromelalgia:Incidence and clinical experience in a single centre in Sweden.Vasa, 2012; 41: 43-48
  Google Scholar
• 5. András C., Csiki Z., Ponyi A., Illés A., Dankó K.: Paraneoplasticrheumatic syndromes. Rheumatol. Int., 2006; 26: 376-382
  Google Scholar
• 6. Borowicz J., Morrison M., Hogan D., Miller R.: Subcutaneous fat necrosis/panniculitisand polyarthritis associated with acinar cell carcinomaof the pancreas: a rare presentation of pancreatitis, panniculitisand polyarthritis syndrome. J. Drugs Dermatol., 2010; 9: 1145-1150
  Google Scholar
• 7. Cacciola R.R., Cipolla A., Di Francesco E., Giustolisi R., CacciolaE.: Treatment of symptomatic patients with essential thrombocythemia:effectiveness of anagrelide. Am. J. Hematol., 2005; 80: 81-83
  Google Scholar
• 8. Carpenter T.O.: Oncogenic osteomalacia – a complex dance offactors. N. Engl. J. Med., 2003; 348: 1705-1708
  Google Scholar
• 9. Chaves M.Y., Pérez P.U.: Cutaneous manifestations of systemicmalignancies: part 2. Actas Dermosifiliogr., 2013; 104: 543-553
  Google Scholar
• 10. Chiari H.: Über die sogenannte fettnecrose. Präger Med. Wochenschr.,1883; 8: 285-286
  Google Scholar
• 11. Ciołkiewicz M., Domysławska I., Ciołkiewicz A., Klimiuk P.A.,Kuryliszyn-Moskal A.: Coexistence of systemic sclerosis, scleroderma-like syndromes and neoplastic diseases. Pol. Arch. Med. Wewn.,2008; 118: 119-126
  Google Scholar
• 12. Cohen P.R.: Granuloma annulare, relapsing polychondritis,sarcoidosis, and systemic lupus erythematosus: conditions whosedermatologic manifestations may occur as hematologic malignancy-associatedmucocutaneous paraneoplastic syndromes. Int. J. Dermatol.,2006; 45: 70-80
  Google Scholar
• 13. Cohen P.R.: Sweet’s syndrome – a comprehensive review of anacute febrile neutrophilic dermatosis. Orphanet J. Rare Dis., 2007; 2: 34
  Google Scholar
• 14. Dahl P.R., Su W.P., Cullimore K.C., Dicken C.H.: Pancreatic panniculitis.J. Am. Acad. Dermatol., 1995; 33: 413-417
  Google Scholar
• 15. DeCross A.J., Sahasrabudhe D.M.: Paraneoplastic Raynaud’s phenomenon.Am. J. Med., 1992; 92: 571-572
  Google Scholar
• 16. Fam A.G.: Paraneoplastic rheumatic syndromes. Baillieres BestPract. Res. Clin. Rheumatol., 2000; 14: 515-533
  Google Scholar
• 17. Gracia-Ramos A.E., Vera-Lastra O.L.: Paraneoplastic rheumaticsyndromes. Rev. Alerg. Mex., 2012; 59: 72-78
  Google Scholar
• 18. Hebbar M., Lassalle P., Janin A., Vanhée D., Bisiau S., HatronP.Y., Tonnel A.B., Gosselin B.: E-selectin expression in salivary endothelialcells and sera of patients with systemic sclerosis. Role ofresident mast cell-derived tumor necrosis factor alpha. ArthritisRheum., 1995; 38: 406-412
  Google Scholar
• 19. Kanai K., Kuwabara S., Misawa S., Hattori T.: Failure of treatmentwith anti-VEGF monoclonal antibody for long-standing POEMS syndrome.Intern. Med., 2007; 46: 311-313
  Google Scholar
• 20. Koch A.E., Halloran M.M., Haskell C.J., Shah M.R., Polverini P.J.:Angiogenesis mediated by soluble forms of E-selectin and vascularcell adhesion molecule-1. Nature, 1995; 376: 517-519
  Google Scholar
• 21. Kocot-Kępska M.: Erytromelalgia – patofizjologia i leczenie. Opisprzypadku klinicznego. Ból, 2009; 10: 60-65
  Google Scholar
• 22. Kurzrock R., Cohen P.R.: Cutaneous paraneoplastic syndromesin solid tumors. Am. J. Med., 1995; 99: 662-671
  Google Scholar
• 23. Kwiatkowska B., Filipowicz-Sosnowska A., Kostrzewa R.: Manifestacjastawowa chorób nowotworowych – demonstracja przypadków.Reumatologia, 2006; 44: 369-373
  Google Scholar
• 24. Launay D., Le Berre R., Hatron P.Y., Peyrat J.P., Hachulla E., DevulderB., Hebbar M.: Association between systemic sclerosis and breastcancer: eight new cases and review of the literature. Clin. Rheumatol.,2004; 23: 516-522
  Google Scholar
• 25. Lorusso L., Hart I.K., Ferrari D., Ngonga G.K., Gasparetto C.,Ricevuti G.: Autonomic paraneoplastic neurological syndromes.Autoimmun. Rev., 2007; 6: 162-168
  Google Scholar
• 26. Lu T.Y., Hill C.L., Pontifex E.K., Roberts-Thomson P.J.: Breastcancer and systemic sclerosis: a clinical description of 21 patients ina population-based cohort study. Rheumatol. Int., 2008; 28: 895-899
  Google Scholar
• 27. Luz F.B., Gaspar T.A., Kalil-Gaspar N., Ramos-e-Silva M.: Multicentricreticulohistiocytosis. J. Eur. Acad. Dermatol. Venereol.,2001; 15: 524-531
  Google Scholar
• 28. Marto G., Klitna Z., Biléu M.C., Barcelos A.: Remitting seronegativesymmetrical synovitis with pitting oedema syndrome, associatedwith prostate adenocarcinoma: a case report. Acta Reumatol.Port., 2010; 35: 358-360
  Google Scholar
• 29. Mattace-Raso F.U., van der Cammen T.J.: Remitting seronegativesymmetrical synovitis with pitting oedema associated with lungmalignancy. Age Ageing, 2007; 36: 470-471
  Google Scholar
• 30. Mayet W.J.: Gastrointestinale Tumoren. Z. Rheumatol., 2011;70: 567-572
  Google Scholar
• 31. Naschitz J.E., Yeshurun D., Zuckerman E., Rosenbaum M., MisselevitchI., Shajrawi I., Boss J.H.: Cancer-associated fasciitis panniculitis.Cancer, 1994; 73: 231-235
  Google Scholar
• 32. Nathanson L., Hall T.C.: Introduction: paraneoplastic syndromes.Semin. Oncol., 1997; 24: 265-268
  Google Scholar
• 33. Nicol C., Quereux G., Renaut J.J., Renac F., Dreno B.: Paraneoplasticmulticentric reticulohistiocytosis. Ann. Dermatol. Venereol.,2011; 138: 405-408
  Google Scholar
• 34. Nurowska-Wrzosek B., Tołodziecka Ł., Gaciong Z.: Erytromelalgia:opis dwóch przypadków klinicznych oraz przegląd literatury.Pol. Arch. Med. Wewn., 2007; 117: 322-326
  Google Scholar
• 35. Peters-Golden M., Wise R.A., Hochberg M., Stevens M.B, WigleyF.M.: Incidence of lung cancer in systemic sclerosis. J. Rheumatol.,1985; 12: 1136-1139
  Google Scholar
• 36. Pfinsgraff J., Buckingham R.B., Killian P.J., Keister S.R., BreretonW.F., Weinblatt M.E., George D.L., Arnett F.C.: Palmar fasciitis andarthritis with malignant neoplasms: a paraneoplastic syndrome.Semin. Arthritis Rheum., 1986; 16: 118-125
  Google Scholar
• 37. Puertas-Abreu E., Polanco E., Azocar M., Mundarain L., NunezSoteloC., Montano R., Vivas F., Noguera Z.T., Marín F., Bellorin O.,Rivas J.G., Toro E., Benzaquen E., Rauseo M., Gutiérrez González L.A.i wsp.: Onset of lupus like syndrome in patients with spondyloarthritistreated with anti-TNF-a. Int. Arch. Med., 2012; 5: 7
  Google Scholar
• 38. Querfeld C., Sollberg S., Huerkamp C., Eckes B., Krieg T.: Pseudosclerodermaassociated with lung cancer: correlation of collagentype I and connective tissue growth factor gene expression. Br. J.Dermatol., 2000; 142: 1228-1233
  Google Scholar
• 39. Qureshi A.A., Saavedra A.: Palmar fasciitis and polyarthritis syndromein patients with ovarian cancer – a case report and review ofthe literature. Hand, 2011; 6: 220-223
  Google Scholar
• 40. Racanelli V., Prete M., Minoia C., Favoino E., Perosa F.: Rheumatic disordersas paraneoplastic syndromes. Autoimmun. Rev., 2008; 7: 352-358
  Google Scholar
• 41. Rugiené R., Dadoniené J., Aleknavičius E., Tikuišis R., Distler J.,Schett G., Venalis P., Venalis A.: Prevalence of paraneoplastic rheumaticsyndromes and their antibody profile among patients withsolid tumours. Clin. Rheumatol., 2011; 30: 373-380
  Google Scholar
• 42. Saiki M., Sakai K., Saiki S., Kitagawa Y., Nakanishi M., Hirose G.:Induction of humoral responses specific for paraneoplastic cerebellardegeneration-associated antigen by whole recombinant yeastimmunization. J. Autoimmun., 2005; 24: 203-208
  Google Scholar
• 43. Sánchez-Guerrero J., Gutiérrez-Urena S., Vidaller A., Reyes E.,Iglesias A., Alarcón-Segovia D.: Vasculitis as a paraneoplastic syndrome.Report of 11 cases and review of the literature. J. Rheumatol.,1990; 17: 1458-1462
  Google Scholar
• 44. Scholz E., Trebing D., Knipping S.: Dermatomyositis with tonsillarcarcinoma: Rare presentation as paraneoplastic syndrome.HNO, 2014; 62: 282-285
  Google Scholar
• 45. Shiel W.C.Jr., Prete P.E., Jason M., Andrews B.S.: Palmar fasciitisand arthritis with ovarian and non-ovarian carcinomas. New syndrome.Am. J. Med., 1985; 79: 640-644
  Google Scholar
• 46. Shimada T., Mizutani S., Muto T., Yoneya T., Hino R., Takeda S.,Takeuchi Y., Fujita T., Fukumoto S., Yamashita T.: Cloning and characterizationof FGF23 as a causative factor of tumor-induced osteomalacia.Proc. Natl. Acad. Sci. USA, 2001; 98: 6500-6505
  Google Scholar
• 47. Śliwińska-Stańczyk P., Maciejewska-Stelmach J., Łącki J.K.: Nowotworya choroby reumatyczne – wielokierunkowe powiązania.Reumatologia, 2007; 45: 92-96
  Google Scholar
• 48. Solans-Laqué R., Pérez-Bocanegra C., Salud-Salvia A., FonollosaPláV., Rodrigo M.J., Armadans L., Simeón-Aznar C.P., Vilardell-TarresM.: Clinical significance of antinuclear antibodies in malignant diseases:association with rheumatic and connective tissue paraneoplasticsyndromes. Lupus, 2004; 13: 159-164
  Google Scholar
• 49. Soubrier M.J., Dubost J.J., Sauvezie B.J.: POEMS syndrome:a study of 25 cases and a review of the literature. French StudyGroup on POEMS Syndrome. Am. J. Med., 1994; 97: 543-553
  Google Scholar
• 50. Szekanecz E., András C., Sándor Z., Antal-Szalmás P., Szántó J.,Tamási L., Kiss E., Szekanecz Z.: Malignancies and soluble tumorantigens in rheumatic diseases. Autoimmun. Rev., 2006; 6: 42-47
  Google Scholar
• 51. Szekanecz Z., Szekanecz E., Bakó G., Shoenfeld Y.: Malignanciesin autoimmune rheumatic diseases. Gerontology, 2011; 57: 3-10
  Google Scholar
• 52. Terkeltaub R.A.: Clinical practice. Gout. N. Engl. J. Med., 2003;349: 1647-1655
  Google Scholar
• 53. Tischler M., Shoenfeld Y.: Paraneoplastic syndromes. W: ShoenfeldY., Fishman P., Gerschwin M. (Hrsg) Cancer and Autoimmunity.Elsevier, Amsterdam, 2000: 121-133
  Google Scholar
• 54. Vasdev V., Bhakuni D., Narayanan K., Jain R.: Intramedullaryfat necrosis, polyarthritis and panniculitis with pancreatic tumor:a case report. Int. J. Rheum. Dis., 2010; 13: e74-e78
  Google Scholar
• 55. Veitch D., Tsai T., Joshua F.: Palmar fasciitis and polyarthritis syndromein pancreatic carcinoma. J. Clin. Rheumatol., 2013; 19: 203-205
  Google Scholar
• 56. Watanabe O., Arimura K., Kitajima I., Osame M, Maruyama I.:Greatly raised vascular endothelial growth factor (VEGF) in POEMSsyndrome. Lancet, 1996; 347: 702
  Google Scholar
• 57. Watts R.A., Merry P.: Familial eosinophilic fasciitis and breastcancer. Br. J. Rheumatol., 1994; 33: 93-94
  Google Scholar
• 58. Zahr Z.A., Baer A.N.: Malignancy in myositis. Curr. Rheumatol.Rep., 2011; 13: 208-215
  Google Scholar

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