Joanna Kűbler-Kiełb , Barbara Adamik
Published: 2000-03-15
GICID: 01.3001.0000.3266
Available language versions: en
Issue: Postepy Hig Med Dosw 2000; 54 (2)
Abstract
The first stage of systemic inflammatory response during sepsis and septic shock is the massive production of proinflammatory cytokines. Numerous clinical trials were done investigating various agents that were thought to stop this reaction. The results, however, were disappointing. Then it was realised that massive production of antiinflammatory cytokines could also be delirious. Persistent immunosupression in the course of sepsis increaased the risk of death. Therefore the proper balance between pro- and antiinflammatory mediators is extremely important and the methodologies available for monitoring immunological status in patients with sepsis and septic shock are currently of great interest.