Jerzy Jochem , Jadwiga Jośko
Published: 2000-11-15
GICID: 01.3001.0000.3312
Available language versions: en
Issue: Postepy Hig Med Dosw 2000; 54 (6)
Abstract
Endothelin-1 (ET-1), a 21-amino acid polypeptide, produced mainly in endothelial cells is the most potent mammalian vasoconstrictor peptide known. Haemorrhagic hypotension is accompanied by the increase in plasma ET-1 concentration. The significance of this effect, however, is not clear. This paper reviews the causes of the rise in ET-1 plasma concentration and the role of ET-1 in cardiovascular regulation in haemorrhagic shock.