SARS-CoV-2, SARS and MERS: Three formidable coronaviruses which have originated from bats
Arezoo Mirzaei 1 , Sharareh Moghim 1Abstract
The recent continuously emerging rampancy of novel coronavirus (SARS-CoV-2) that started in Wuhan in late December 2019 has become an international public health emergency and is still spreading rapidly in the world. Up to October 11, 2020, 37.109.6851 confirmed cases of COVID-19 have been announced with 2.8 percent death, which means 1.070.355 confirmed death cases. At the moment, a specific vaccine or drug for the new coronavirus is not available; thus, the development of a drug with far-reaching HCoV inhibitory activity is an urgent medical need. It is, however, vital to first comprehend the nature of this family and other coronaviruses that have caused the outbreak. Here, we relate the epidemiological and virological characteristics of the COVID-19, SARS, and MERS rampancy.
References
- 1. Ahmadpoor P., Rostaing L.: Why the immune system fails tomount an adaptive immune response to a COVID‐19 infection.Transpl. Int., 2020; 33: 824–825
Google Scholar - 2. Al-Tawfiq J.A., Zumla A., Memish Z.A.: Travel implications ofemerging coronaviruses: SARS and MERS-CoV. Travel Med. Infect.Dis., 2014; 12: 422–428
Google Scholar - 3. Assiri A., McGeer A., Perl T.M., Price C.S., Al Rabeeah A.A., CummingsD.A., Alabdullatif Z.N., Assad M., Almulhim A., MakhdoomH., Madani H., Alhakeem R., Al-Tawfiq J.A., Cotton M., Watson S.J.:Hospital outbreak of Middle East respiratory syndrome coronavirus.N. Engl. J. Med., 2013; 369: 407–416
Google Scholar - 4. Baud D., Qi X., Nielsen-Saines K., Musso D., Pomar L., Favre G.:Real estimates of mortality following COVID-19 infection. LancetInfect. Dis., 2020; 20: 773
Google Scholar - 5. Bosch B.J., van der Zee R., de Haan C.A., Rottier P.J.: The coronavirusspike protein is a class I virus fusion protein: Structural andfunctional characterization of the fusion core complex. J. Virol.,2003; 77: 8801–8811
Google Scholar - 6. Cai X.F., Chen J., Hu J.L., Long Q.X., Deng H.J., Liu P., Fan K., LiaoP., Liu B.Z., Wu G.C., Chen Y.K., Li Z.J., Wang K., Zhang X.L., TianW.G., et al.: A peptide-based magnetic chemiluminescence enzymeimmunoassay for serological diagnosis of corona virus disease 2019 J. Infect. Dis., 2020; 222: 189–193
Google Scholar - 7. Carter L.J., Garner L.V., Smoot J.W., Li Y., Zhou Q., Saveson C.J.,Sasso J.M., Gregg A.C., Soares D.J., Beskid T.R., Jervey S.R., Liu C.:Assay techniques and test development for COVID-19 diagnosis.ACS Cent. Sci., 2020; 6: 591–605
Google Scholar - 8. Cascella M., Rajnik M., Cuomo A., Dulebohn S.C., Di Napoli R.:Features, evaluation and treatment coronavirus (COVID-19). Stat-Pearls Publishing, 2020
Google Scholar - 9. Chan J.F., Kok K.H., Zhu Z., Chu H., To K.K., Yuan S., Yuen K.Y.:Genomic characterization of the 2019 novel human-pathogeniccoronavirus isolated from a patient with atypical pneumonia aftervisiting Wuhan. Emerg. Microbes Infect., 2020; 9: 221–236
Google Scholar - 10. Chen Z.M., Fu J.F., Shu Q., Chen Y.H., Hua C.Z., Li F.B., Lin R.,Tang L.F., Wang T.L., Wang W., WangY.S., Xu W.Z., Yang Z.H., Ye S.,Yuan T.M., Zhang C.M., Zhang Y.Y.: Diagnosis and treatment recommendationsfor pediatric respiratory infection caused by the 2019novel coronavirus. World J. Pediatr., 2020: 16: 240–246
Google Scholar - 11. de Wit E., van Doremalen N., Falzarano D., Munster V.J.: SARSand MERS: Recent insights into emerging coronaviruses. Nat. Rev.Microbiol., 2016;. 14: 523–534
Google Scholar - 12. Donnelly C.A., Ghani A.C., Leung G.M., Hedley A.J., Fraser C,Riley S., Abu-Raddad L.J., Ho L.M., Thach T.Q., Chau P., Chan K.P.,Lam T.H., Tse L.Y., Tsang T., Liu S.H., Kong J.H., Lau E.M., FergusonN.M., Anderson R.M.: Epidemiological determinants of spread ofcausal agent of severe acute respiratory syndrome in Hong Kong.Lancet, 2003; 361: 1761–1766
Google Scholar - 13. Drosten C., Günther S., Preiser W., van der Werf S., Brodt H.R.,Becker S., Rabenau H., Panning M., Kolesnikova L., Fouchier R.A.,Berger A., Burguière A.M., Cinatl J., Eickmann M., Escriou N., etal.: Identification of a novel coronavirus in patients with severeacute respiratory syndrome. N. Engl. J. Med., 2003; 348: 1967–1976
Google Scholar - 14. Du Z., Xu X., Wu Y., Wang L., Cowling B.J., Meyers L.A.: Serialinterval of COVID-19 among publicly reported confirmed cases.Emerg. Infect. Dis., 2020; 26: 1341–1343
Google Scholar - 15. Fehr A.R., Perlman S.: Coronaviruses: an overview of their replicationand pathogenesis. In: Coronaviruses. Methods and Protocols,eds.: H.J. Maier, E. Bickerton, P. Britton. Springer, 2015: 1–23
Google Scholar - 16. Fields B.N., Knipe D.M., Howley P.M.: Fundamental Virology.Lippincott-Raven Philadelphia; 1996
Google Scholar - 17. Gallagher T.M., Buchmeier M.J.: Coronavirus spike proteins inviral entry and pathogenesis. Virology, 2001; 279: 371–374
Google Scholar - 18. García L.F.: Immune response, inflammation, and the clinicalspectrum of COVID-19. Front. Immunol., 2020; 11: 1441 19 Gorbalenya A.E., Baker S.C., Baric R.S., de Groot R.J., DrostenC., Gulyaeva A.A., Haagmans B.L., Lauber C., LeontovichA.M., Neuman B.W., Penzar D., Perlman S., Poon L.L., SamborskiyD., Sidorov I.A., et al.: Severe acute respiratory syndromerelatedcoronavirus: The species and its viruses – a statementof the Coronavirus Study Group. BioRxiv, 2020. doi: https://doi.org/10.1101/2020.02.07.937862
Google Scholar - 19. MedRxiv, 2020: https://doi.org/10.1101/2020.03.03.20029983
Google Scholar - 20. Gralinski L.E., Menachery V.D.: Return of the Coronavirus:2019-nCoV. Viruses, 2020; 12: 135
Google Scholar - 21. Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X., Liu L.,Shan H., Lei C.L, Hui D.S., Du B., Li L.J., Zeng G., Yuen K.Y., ChenR.C., et al.: Clinical characteristics of coronavirus disease 2019 inChina. N. Engl. J. Med., 2020; 382: 1708–1720
Google Scholar - 22. Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L.,Luo S.W., Li P.H., Zhang L.J., Guan Y.J., Butt K.M., Wong K.L., ChanK.W., Lim W., Shortridge K.F., Yuen K.Y., Peiris J.S.M., Poon L.L.: Isolationand characterization of viruses related to the SARS coronavirusfrom animals in southern China. Science, 2003; 302: 276–278
Google Scholar - 23. Haagmans B.L., Al Dhahiry S.H., Reusken C.B., Raj V.S., GalianoM., Myers R., Godeke G.J., Jonges M., Farag E., Diab A., Ghobashy H.,Alhajri F., Al-Thani M., Al-Marri S.A., Al Romaihi H.E., et al.: MiddleEast respiratory syndrome coronavirus in dromedary camels:An outbreak investigation. Lancet Infect. Dis., 2014; 14: 140–145
Google Scholar - 24. Habibzadeh P., Stoneman E.K.: The novel coronavirus: A bird’seye view. Int. J. Occup. Environ. Med., 2020; 11: 65–71
Google Scholar - 25. Han Q., Lin Q., Jin S., You L.: Recent insights into 2019-nCoV:A brief but comprehensive review. J. Infect., 2020; 80: 373–377
Google Scholar - 26. Hijawi B., Abdallat M., Sayaydeh A., Alqasrawi S., Haddadin A.,Jaarour N., Alsheikh S., Alsanouri T.: Novel coronavirus infectionsin Jordan, April 2012: Epidemiological findings from a retrospectiveinvestigation. East. Mediterr. Health J., 2013; 19: S12–S18
Google Scholar - 27. Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., HerrlerT., Erichsen S., Schiergens T.S., Herrler G., Wu N.H., Nitsche A.,Müller M.A., Drosten C., Pöhlmann S.: SARS-CoV-2 cell entry dependson ACE2 and TMPRSS2 and is blocked by a clinically provenprotease inhibitor. Cell, 2020; 181: 271–280
Google Scholar - 28. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., FanG., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., et al.: Clinicalfeatures of patients infected with 2019 novel coronavirus in Wuhan,China. Lancet, 2020; 395: 497–506
Google Scholar - 29. Huang C., Wen T., Shi F.J., Zeng X.Y., Jiao Y.J.: Rapid detection ofIgM antibodies against the SARS-CoV-2 virus via colloidal gold nanoparticle-based lateral-flow assay. ACS Omega, 2020; 5: 12550–12556
Google Scholar - 30. Hunter J.C., Nguyen D., Aden B., Al Bandar Z., Al Dhaheri W.,Abu Elkheir K., Khudair A., Al Mulla M., El Saleh F., ImambaccusH., Al Kaabi N., Sheikh F.A., Sasse J., Turner A., Abdel Wareth L.,et al.: Transmission of Middle East respiratory syndrome coronavirusinfections in healthcare settings, Abu Dhabi. Emerg. Infect.Dis., 2016; 22: 647–656
Google Scholar - 31. Kanne J.P.: Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: Key points for the radiologist.Radiology, 2020; 295: 16–17
Google Scholar - 32. Lee N., Hui D., Wu A., Chan P., Cameron P., Joynt G.M., AhujaA., Yung M.Y., Leung C.B., To K.F., Lui S.F., Szeto C.C., Chung S.,Sung J.J.: A major outbreak of severe acute respiratory syndromein Hong Kong. N. Engl. J. Med., 2003; 348: 1986–1994
Google Scholar - 33. Lee P.I., Hsueh P.R.: Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV. J. Microbiol. Immunol.Infect., 2020; 53: 365–367
Google Scholar - 34. Leo Y.S., Chen M., Heng B.H., Lee C.C.: Severe acute respiratorysyndrome-Singapore, 2003. MMWR Morb. Mortal. Wkly. Rep.,2003; 52: 405–411
Google Scholar - 35. Leung G.M., Hedley A.J., Ho L.M., Chau P., Wong I.O., ThachT.Q., Ghani A.C., Donnelly C.A., Fraser C., Riley S., Ferguson N.M.,Anderson R.M., Tsang T., Leung P.Y., Wong V., Chan J.C., Tsui E., LoS.V., Lam T.H.: The epidemiology of severe acute respiratory syndromein the 2003 Hong Kong epidemic: An analysis of all 1755patients. Ann. Intern. Med., 2004; 141: 662–673
Google Scholar - 36. Li P., Fu J.B., Li K.F., Liu J.N., Wang H.L., Liu L.J., Chen Y., ZhangY.L., Liu S.L., Tang A., Tong Z.D., Yan J.B.: Transmission of COVID-19in the terminal stages of the incubation period: A familial cluster.Int. J. Infect. Dis., 2020; 96: 452–453
Google Scholar - 37. Liu Y., Gayle A.A., Wilder-Smith A., Rocklöv J.: The reproductivenumber of COVID-19 is higher compared to SARS coronavirus.J. Travel Med., 2020; 27: taaa021
Google Scholar - 38. Lu C.W., Liu X.F., Jia Z.F.: 2019-nCoV transmission through theocular surface must not be ignored. Lancet, 2020; 395: e39
Google Scholar - 39. Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., Wang W., SongH., Huang B., Zhu N., Bi Y., Ma X., Zhan F., WangL., Hu T., et al.:Genomic characterisation and epidemiology of 2019 novel coronavirus:Implications for virus origins and receptor binding. Lancet,2020; 395: 565–574
Google Scholar - 40. Mirzaie A., Halaji M., Dehkordi F.S., Ranjbar R., NoorbazarganH.: A narrative literature review on traditional medicine optionsfor treatment of corona virus disease 2019 (COVID-19). Complement.Ther. Clin. Pract., 2020; 40: 101214
Google Scholar - 41. Nishiura H., Kobayashi T., Yang Y., Hayashi K.., Miyama T., KinoshitaR., Linton N.M., Jung S.M., Yuan B., Suzuki A., AkhmetzhanovA.R.: The rate of underascertainment of novel coronavirus(2019-nCoV) infection: Estimation using Japanese passengers dataon evacuation flights. J. Clin. Med., 2020; 9: 419
Google Scholar - 42. Pasternak A.O., Spaan W.J., Snijder E.J.: Nidovirus transcription:How to make sense…? J. Gen. Virol., 2006; 87: 1403–1421
Google Scholar - 43. Perlman S., Netland J.: Coronaviruses post-SARS: Updateon replication and pathogenesis. Nat. Rev. Microbiol., 2009;7: 439–450
Google Scholar - 44. Phan T.: Novel coronavirus: From discovery to clinical diagnostics.Infect. Genet. Evol., 2020; 79: 104211
Google Scholar - 45. Postnikova E.N., Pettitt J., Van Ryn C.J., Holbrook M.R., BollingerL., Yú S., Caì Y., Liang J., Sneller M.C., Jahrling P.B., HensleyL.E., Kuhn J.H., Fallah M.P., Bennett R.S., Reilly C.: Scalable, semiautomatedfluorescence reduction neutralization assay for qualitativeassessment of Ebola virus-neutralizing antibodies in humanclinical samples. PLoS One, 2019; 14: e0221407
Google Scholar - 46. Poutanen S.M., Low D.E., Henry B., Finkelstein S., Rose D.,Green K., Tellier R., Draker R., Adachi D., Ayers M., Chan A.K., SkowronskiD.M., Salit I., Simor A.E., Slutsky A.S., et al: Identificationof severe acute respiratory syndrome in Canada. N. Engl. J. Med.,2003; 348: 1995–2005
Google Scholar - 47. Raj V.S., Farag E.A., Reusken C.B., Lamers M.M., Pas S.D., VoermansJ., Smits S.L., Osterhaus A.D., Al-Mawlawi N., Al-Romaihi H.E.,Al. Hajri M.M., El-Sayed A.M., Mohran K.A., Ghobashy H., AlhajriF., et al.: Isolation of MERS coronavirus from a dromedary camel,Qatar, 2014. Emerg. Infect. Dis., 2014; 20: 1339–1342
Google Scholar - 48. Raj V.S., Mou H., Smits S.L., Dekkers D.H., Müller M.A., DijkmanR., Muth D., Demmers J.A., Zaki A., Fouchier R.A., Thiel V.,Drosten C., Rottier P.J., Osterhaus A.D., Bosch B.J., et al.: Dipeptidylpeptidase 4 is a functional receptor for the emerging humancoronavirus-EMC. Nature, 2013; 495: 251–254
Google Scholar - 49. Reusken C.B., Haagmans B.L., Müller M.A., Gutierres C., GodekeG.J., Meyer B., Muth D., Raj V.S., Smits-De Vries L., Corman V.M.,Drexler J.F., Smits S.L., El Tahir Y.E., De Sousa R., van Beek J., et al.:Middle East respiratory syndrome coronavirus neutralising serumantibodies in dromedary camels: A comparative serological study.Lancet Infect. Dis., 2013; 13: 859–866
Google Scholar - 50. Shi Y., Wang Y., Shao C., Huang J., Gan J., Huang X., Bucci E., PiacentiniM., Ippolito G., Melino G.: COVID-19 infection: The perspectiveson immune responses. Cell Death Differ., 2020; 27: 1451–1454
Google Scholar - 51. Tang Y.W., Schmitz J.E., Persing D.H., Stratton C.W.: Laboratorydiagnosis of COVID-19: Current issues and challenges. J. Clin.Microbiol., 2020; 58: e00512–20
Google Scholar - 52. Tindale L., Coombe M., Stockdale J.E., Garlock E.S., Lau W.Y.,Saraswat M., Lee Y.H., Zhang L., Chen D., Wallinga J., Colijn C.: Transmissioninterval estimates suggest pre-symptomatic spread of COVID-
Google Scholar - 53. Tu W., Tang H., Chen F., Wei Y., Xu T., Liao K., Xiang N., Shi G., LiQ., Feng Z.: Epidemic update and risk assessment of 2019 novel coronavirus– China, January 28, 2020. China CDC Wkly., 2020; 2: 83–86
Google Scholar - 54. Wan Y., Shang J., Graham R., Baric R.S., Li F.: Receptor recognitionby the novel coronavirus from Wuhan: An analysis basedon decade-long structural studies of SARS coronavirus. J. Virol.,2020; 94: e00127–20
Google Scholar - 55. Wandtke T., Woźniak J., Kopiński P.: Aptamers in diagnosticsand treatment of viral infections. Viruses, 2015; 7: 751–780
Google Scholar - 56. Wang J.T. Sheng W.H., Fang C.T., Chen Y.C., Wang J.L., Yu C.J.,Chang S.C., Yang P.C.: Clinical manifestations, laboratory findings,and treatment outcomes of SARS patients. Emerg. Infect.Dis., 2004; 10: 818–824
Google Scholar - 57. Wertheim J.O.: A glimpse into the origins of genetic diversityin the severe acute respiratory syndrome coronavirus 2. Clin. Infect.Dis., 2020; 71: 721–722
Google Scholar - 58. Wise J.: Patient with new strain of coronavirus is treated inintensive care at London hospital. Br. Med. J., 2012; 345: e6455
Google Scholar - 59. Wu F., Zhao S., Yu B., Chen Y.M., Wang W., Song Z.G., Hu Y., TaoZ.W., Tian J.H., Pei Y.Y., Yuan M.L., Zhang Y.L., Dai F.H., Liu Y., WangO.M., et al.: A new coronavirus associated with human respiratorydisease in China. Nature, 2020; 579: 265–269
Google Scholar - 60. Wu J.L., Tseng W.P., Lin C.H., Lee T.F., Chung M.Y., Huang C.H.,Chen S.Y., Hsueh P.R., Chen S.C.: Four point-of-care lateral flow immunoassaysfor diagnosis of COVID-19 and for assessing dynamicsof antibody responses to SARS-CoV-2. J. Infect., 2020; 81: 435–442
Google Scholar - 61. Xia S., Yan L., Xu W., Agrawal A.S., Algaissi A., Tseng C.T., WangQ., Du L., Tan W., Wilson I.A., Jiang S., Yang B., Lu L.: A pan-coronavirusfusion inhibitor targeting the HR1 domain of human coronavirusspike. Sci. Adv., 2019; 5: eaav4580
Google Scholar - 62. Xu J., Zhao S., Teng T., Abdalla A.E., Zhu W., Xie L., Wang Y.,Guo X.: Systematic comparison of two animal-to-human transmittedhuman coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses,2020; 12: 244
Google Scholar - 63. Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., Liu S.,Zhao P., Liu H., Zhu L., Tai Y., Bai C., Gao T., Song J., Xia P., Dong J.,Zhao J., Wang F.S.: Pathological findings of COVID-19 associatedwith acute respiratory distress syndrome. Lancet Respir. Med.,2020; 8: 420–422
Google Scholar - 64. Zaigham M., Andersson O.: Maternal and perinatal outcomeswith COVID‐19: A systematic review of 108 pregnancies. Acta Obstet.Gynecol. Scand., 2020: 99: 823–829
Google Scholar - 65. Zaki A.M., van Boheemen S., Bestebroer T.M., Osterhaus A.D.,Fouchier R.A.: Isolation of a novel coronavirus from a man withpneumonia in Saudi Arabia. N. Engl. J. Med., 2012; 367: 1814–1820
Google Scholar - 66. Zhang F., Abudayyeh O.O., Gootenberg J.S.: A protocol fordetection of COVID-19 using CRISPR diagnostics. https://www.broadinstitute.org/files/publications/special/COVID-19%20detection%20(updated).pdf
Google Scholar - 67. Zhang H., Kang Z., Gong H., Xu D., Wang J., Li Z., Li Z., Cui X.,Xiao J., Zhan J., Meng T., Zhou W., Liu J., Xu H.: Digestive system isa potential route of COVID-19 infection: An analysis of single-cellcoexpression pattern of key proteins in viral entry process. Gut,2020; 69: 1010–1018
Google Scholar - 68. Zhang W., Du R.H., Li B., Zheng X.S., Yang X.L., Hu B., WangY.Y., Xiao G.F., Yan B., Shi Z.L., Zhou P.: Molecular and serologicalinvestigation of 2019-nCoV infected patients: Implication of multipleshedding routes. Emerg. Microbes Infect., 2020; 9: 386–389
Google Scholar - 69. Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., SiH.R., Zhu Y., Li B., Huang C.L., Chen H.D., Chen J., Luo Y., Guo H.,Jiang R.D., et al.: Discovery of a novel coronavirus associated withthe recent pneumonia utbreak in humans and its potential batorigin. BioRxiv, 2020. https://doi.org/10.1101/2020.01.22.914952
Google Scholar - 70. Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., Si H.R.,Zhu Y., Li B., Huang C.L., Chen H.D., Chen J., Luo Y., Guo H., JiangR.D., et al.: A pneumonia outbreak associated with a new coronavirusof probable bat origin. Nature, 2020; 579: 270–273
Google Scholar