[Selective cyclooxygenase 2 inhibitors (COX-2)]

F Mejza ¹ , E Nizankowska

1. Klinika Pulmonologii, II Katedra Chorób Wewnetrznych Collegium Medicum UJ wKrakowie.

Published:

GICID: 01.3001.0000.3333

Available language versions: en pl

Issue: Postepy Hig Med Dosw 2001; 55 (2)

Abstract

Cyclooxygenase is key enzyme in the prostaglandin synthesis. It exists in two isoforms, which have distinct functions in the organism. Cyclooxygenase-2 (COX-2) participates in the pathophysiology of inflammation. Differences in the molecular structure of cyclooxygenases allowed to develop drug that selectively inhibit that isoform. Recently, selective inhibitors of COX-2 were introduced into therapy, providing new opportunities to the treatment of inflammation.