REVIEW ARTICLE
[Soluble TNF-alpha receptors]
E Jabłońska 1
1. Zakład Immunopatologii Akademii Medycznej w Białymstoku.
Published:
GICID: 01.3001.0000.3151
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1997; 51 (5)
Abstract
Soluble cytokine receptors are more general phenomena and play a wider physiological role in the regulation of the immune system than previously recognized. Soluble TNF receptors–sTNF-Rp55 and sTNF-Rp75 by ability to bind to free TNF-alpha might play a regulatory role in a variety of normal and abnormal reactions mediated by TNF-alpha. Increase of sTNF-Rs levels have been observed in the serum of patients with a different diseases. Measurement of soluble TNF receptors concentrations seems to be a significant indicator in prognostic estimation of some diseases. Additionally, bioengineered soluble receptors may prove useful as specific cytokine-inhibiting therapeutic agents.