COMMENTARY ON THE LAW
The genetic basis of childhood nephrotic syndrome
Iwona Maruniak-Chudek 1 , Zofia Niemir 2 , Janusz Świetliński 1
1. Klinika Intensywnej Terapii i Patologii Noworodka, Śląskiej Akademii Medycznej w Katowicach
2. Pracownia Nefrologii Molekularnej, Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnętrznych Akademii Medycznej im. K. Marcinkowskiego w Poznaniu
Published: 2004-11-24
GICID: 01.3001.0000.3615
Available language versions: en pl
Issue: Postepy Hig Med Dosw 2004; 58 (0)
Abstract
Great progress has been made of late in understanding the mechanisms of proteinuria, the structure and function of the slit diaphragm, and the genetic background of congenital nephrotic syndromes in new borns and infants. This paper presents recent achievements of molecular genetics in unraveling the causes of inherited disorders, e.g. Finnish-type nephrotic, Denys-Drash and Frasier’s syndromes, as well as sporadic focal-segmental glomerulosclerosis. A change in the routine policy used in evaluating the causes of childhood nephrotic syndrome is discussed