REVIEW ARTICLE
The influence of IGF-1 on fetal growth during pregnancy complicated by gestational diabetes mellitus
Tomasz Gęca 1 , Maciej Kwiatek 1 , Arkadiusz Krzyżanowski 1 , Anna Kwaśniewska 11. 1Katedra i Klinika Położnictwa i Patologii Ciąży Uniwersytetu Medycznego w Lublinie,
Published: 2018-07-16
DOI: 10.5604/01.3001.0012.1967
GICID: 01.3001.0012.1967
Available language versions: en pl
Issue: Postepy Hig Med Dosw 2018; 72 : 623-626
Abstract
Insulin-like growth factor-1 (IGF-1) is an important part of IGF system. The structure and function of IGF-1 are similar to that of insulin. Thus, IGF-1 may participate both in the gestational diabetes mellitus (GDM) pathogenesis and the development of some complications. IGF-1, as one of the most important growth factors “in utero”, may influence the intrauterine growth leading to fetal macrosomia. The aim of the study was to present the structure and function of IGF-1 in terms of carbohydrate metabolism disturbances and to determine the role of IGF-1 on fetal growth during pregnancy complicated by GDM. Fetal growth is an extremely complex process and depends on many factors, including IGF-1 concentration.