R Adamiec 1
1. Katedra i Klinika Nefrologii AM, Wrocławiu.
Published:
GICID: 01.3001.0000.2892
Available language versions: en pl
Issue: Postepy Hig Med Dosw 1992; 46 (1)
Abstract
The calcium pathway of Cyclosporine A (CyA) action on peripheral blood lymphocytes was assessed with regard to the literature data and self observations of kidney graft recipients. A significant relation between the immunosuppressive action of the drug and intracellular concentrations of Ca2+ is intimately linked with the regulatory potential of calmodulin. Because of the widespread clinical use of calcium channel blockers also considered influence of these drugs on immunosuppression by CyA and their importance in reducing its nephrotoxicity.