The role of immune system cells and their receptors in viral infections – selected data
Joanna Śliwa-Dominiak 1 , Beata Tokarz-Deptuła 2 , Wiesław Deptuła 1Abstract
The study of the immune system started about a hundred years ago with the phagocytosis experiments of Mechnikov. That which is now referred to as non-specific cell-mediated immunity was quickly linked to studies related to, inter alia, the immunity determined by antibodies (humoral), which has long been considered as the first line of defense against diseases caused by micro-organisms, including viruses. Despite their small size, viruses have a huge impact on the host, as they produce substances that stimulate the antiviral response and affect it. The paper presents selected data on participation of immune system cells and their receptors in viral infections, as the host cells have evolved a number of specific cellular and humoral components of the signaling networks that are involved in the detection and the host’s response to viral infections.
References
- 1. Beckham J.D., Tuttle K., Tyler K.L.: Reovirus activates transforminggrowth factor β and bone morphogenetic protein signaling pathwaysin the central nervous system that contribute to neuronal survivalfollowing infection. J. Virol., 2009; 83: 5035-5045
Google Scholar - 2. Belkaid Y., Tarbell K.: Regulatory T cells in the control of hostmicroorganisminteractions. Annu. Rev. Immunol., 2009; 27: 551-589
Google Scholar - 3. Bermejo-Martin J.F., Ortiz de Lejarazu R., Pumarola T., Rello J.,Almansa R., Ramírez P., Martin-Loeches I., Varillas D., Gallegos M.C.,Serón C., Micheloud D., Gomez J.M., Tenorio-Abreu A., Ramos M.J.,Molina M.L. i wsp.: Th1 and Th17 hypercytokinemia as early hostresponse signature in severe pandemic influenza. Crit. Care, 2009;13: R201
Google Scholar - 4. Bowie A.G., Unterholzner L.: Viral evasion and subversion ofpattern-recognition receptor signalling. Nat. Rev. Immunol., 2008;8: 911-922
Google Scholar - 5. Brady M.T., MacDonald A.J., Rowan A.G., Mills K.H.: Hepatitis Cvirus non-structural protein 4 suppresses Th1 responses by stimulatingIL-10 production from monocytes. Eur. J. Immunol., 2003;33: 3448-3457
Google Scholar - 6. Brockman M.A., Kwon D.S., Tighe D.P., Pavlik D.F., Rosato P.C., SelaJ., Porichis F., Le Gall S., Waring M.T., Moss K., Jessen H., Pereyra F.,Kavanagh D.G., Walker B.D., Kaufmann D.E.: IL-10 is up-regulatedin multiple cell types during viremic HIV infection and reversiblyinhibits virus-specific T cells. Blood, 2009; 114: 346-356
Google Scholar - 7. Brooks D.G., Trifilo M.J., Edelmann K.H., Teyton L., McGavern D.B.,Oldstone M.B.: Interleukin-10 determines viral clearance or persistencein vivo. Nat. Med., 2006; 12: 1301-1309
Google Scholar - 8. Culley F.J., Pennycook A.M., tregoning J.S., Hussell T., OpenshawP.J.: Differential chemokine expression following respiratory virus infectionreflects Th1- or Th2-biased immunopathology. J. Virol., 2006;80: 4521-4527
Google Scholar - 9. Deptuła W., Niedźwiedzka P., Tokarz-Deptuła B.: Znaczenie receptorówToll-podobnych u zwierząt gospodarskich. Medycyna Wet., 2007;63: 900-903
Google Scholar - 10. Deptuła W., Śliwa-Dominiak J.: Immunity in viral infections – selecteddata. Adv. Agr. Sci., 2010; 13: 83-88
Google Scholar - 11. Deptuła W., Tokarz-Deptuła B., Niedźwiedzka P.: Rola i znaczeniereceptorów Toll-podobnych w odporności. Postępy Mikrobiol., 2006;45: 221-231
Google Scholar - 12. Deptuła W., Tokarz-Deptuła B., Stosik M.: Immunologia dla biologów.Wydanie nowe. Wyd. US, Szczecin, 2008
Google Scholar - 13. Favre D., Lederer S., Kanwar E., Ma Z.M., Proll S., Kasakow Z., MoldJ., Swainson L., Barbour J.D., Baskin C.R., Palermo R., Pandrea I., MillerC.J., Katze M.G., McCune J.M.: Critical loss of the balance between Th17and T regulatory cell populations in pathogenic SIV infection. PLoSPathog., 2009; 5: e1000295
Google Scholar - 14. Foy E., Li K., Sumpter R.Jr., Loo Y.M., Johnson C.L., Wang C., FishP.M., Yoneyama M., Fujita T., Lemon S.M., Gale M.Jr.: Control of antiviraldefenses through hepatitis C virus disruption of retinoic acid-induciblegene-I signaling. Proc. Natl. Acad. Sci. USA, 2005; 102: 2986-2991
Google Scholar - 15. Foy E., Li K., Wang C., Sumpter R.Jr., Ikeda M., Lemon S.M., GaleM.Jr.: Regulation of interferon regulatory factor-3 by the hepatitis Cvirus serine protease. Science, 2003; 300: 1145-1148
Google Scholar - 16. Hyodo N., Nakamura I., Imawari M.: Hepatitis B core antigen stimulatesinterleukin-10 secretion by both T cells and monocytes from peripheralblood of patients with chronic hepatitis B virus infection. Clin.Exp. Immunol., 2004; 135: 462-466
Google Scholar - 17. Ikeda K., Inuoe S.: TRIM proteins as RING finger E3 ubiquitin ligases.Adv. Exp. Med. Biol., 2012; 770: 27-37
Google Scholar - 18. Iwasaki A., Medzhitov R.: Toll-like receptor control of the adaptiveimmune responses. Nat. Immunol., 2004; 5: 987-995
Google Scholar - 19. Kędziora S., Słotwiński R.: Molekularne mechanizmy towarzyszącerozpoznawaniu patogenu przez receptory wrodzonej odporności. PostępyHig. Med. Dośw., 2009; 63: 30-38
Google Scholar - 20. Kotenko S.V., Saccani S., Izotova L.S., Mirochnitchenko O.V., PestkaS.: Human cytomegalovirus harbors its own unique IL-10 homolog(cmvIL-10). Proc. Natl. Acad. Sci. USA, 2000; 97: 1695-1700
Google Scholar - 21. Koyama S., Ishii K.J., Coban C., Akira S.: Innate immune response toviral infection. Cytokine, 2008; 43: 336-341
Google Scholar - 22. Lanteri M.C., O’Brien K.M., Purtha W.E., Cameron M.J., Lund J.M.,Owen R.E., Heitman J.W., Custer B., Hirschkorn D.F., Tobler L.H., KielyN., Prince H.E., Ndhlovu L.C., Nixon D.F., Kamel H.T., Kelvin D.J., BuschM.P., Rudensky A.Y., Diamond M.S., Norris P.J.: tregs control the developmentof symptomatic West Nile virus infection in humans and mice.J. Clin. Invest., 2009; 119: 3266-3277
Google Scholar - 23. Li K., Foy E., Ferreon J.C., Nakamura M., Ferreon A.C., Ikeda M., RayS.C., Gale M.Jr., Lemon S.M.: Immune evasion by hepatitis C virus NS3/4Aprotease-mediated cleavage of the Toll-like receptor 3 adaptor proteinTRIF. Proc. Natl. Acad. Sci. USA, 2005; 102: 2992-2997
Google Scholar - 24. Li M.O., Flavell R.A.: TGF-β: a master of all T cell trades. Cell, 2008;134: 392-404
Google Scholar - 25. McNab F.W., Rajsbaum R., Stoye J.P., O’Garra A.: Tripartite-motifproteins and innate immune regulation. Curr. Opin. Immunol., 2011;23: 46-56
Google Scholar - 26. Meroni G., Diez-Roux G.: TRIM/RBCC, a novel class of ‘single proteinRING finger’ E3 ubiquitin ligases. Bioessays, 2005; 27: 1147-1157
Google Scholar - 27. Niedźwiedzka-Rystwej P., Herberg M., Deptuła W.: Biology and roleof NK cells – selected data. Centr. Eur. J. Immunol., 2012; 37: 399-404
Google Scholar - 28. Niedźwiedzka-Rystwej P., Tokarz-Deptuła B., Deptuła W.: The roleof TLRs in viral infections – selected data. Centr. Eur. J. Immunol., 2013;38: 118-121
Google Scholar - 29. Nurden A.T.: Platelets, inflammation and tissue regeneration.Thromb. Haemost., 2011; 105: S13-S33
Google Scholar - 30. O’Connor W.Jr., Kamanaka M., Booth C.J., Town T., Nakae S., IwakuraY., Kolls J.K., Flavell R.A.: A protective function for interleukin 17A in Tcell-mediated intestinal inflammation. Nat. Immunol., 2009; 10: 603-609
Google Scholar - 31. Ozato K., Shin D.M., Chang T.H., Morse H.C.3rd: TRIM family proteinsand their emerging roles in innate immunity. Nat. Rev. Immunol.,2008; 8: 849-860
Google Scholar - 32. Pichlmair A., Reis e Sousa C.: Innate recognition of viruses. Immunity,2007; 27: 370-383
Google Scholar - 33. Rajsbaum R., Stoye J.P., O’Garra A.: Type I interferon-dependentand –independent expression of tripartite motif proteins in immunecells. Eur. J. Immunol., 2008; 38: 619-630
Google Scholar - 34. Rouse B.T., Sehrawat S.: Immunity and immunopathology to viruses:what decides the outcome? Nat. Rev. Immunol., 2010; 10: 514-526
Google Scholar - 35. Rowan A.G., Fletcher J.M., Ryan E.J., Moran B., Hegarty J.E., O’FarrellyC., Mills K.H.: Hepatitis C virus-specific Th17 cells are suppressed by virus-inducedTGF-β. J. Immunol., 2008; 181: 4485-4494
Google Scholar - 36. Ruckwardt T.J., Bonaparte K.L., Nason M.C., Graham B.S.: RegulatoryT cells promote early influx of CD8+ T cells in the lungs of respiratorysyncytial virus-infected mice and diminish immunodominance disparities.J. Virol., 2009; 83: 3019-3028
Google Scholar - 37. Schultz-Cherry S., Hinshaw V.S.: Influenza virus neuraminidase activateslatent transforming growth factor β. J. Virol., 1996; 70: 8624-8629
Google Scholar - 38. Shaw M.H., Kamada N., Warner N., Kim Y.G., Nunez G.: The everexpandingfunction of NOD2: autophagy, viral recognition, and T cellactivation. Trends Immunol., 2011; 32: 73-79
Google Scholar - 39. Smit J.J., Rudd B.D., Lukacs N.W.: Plasmacytoid dendritic cells inhibitpulmonary immunopathology and promote clearance of respiratorysyncytial virus. J. Exp. Med., 2006; 203: 1153-1159
Google Scholar - 40. Sumpter R.Jr., Loo Y.M., Foy E., Li K., Yoneyama M., Fujita T., LemonS.M., Gale M.Jr.: Regulating intracellular antiviral defense and permissivenessto hepatitis C virus RNA replication through a cellular RNAhelicase, RIG-I. J. Virol., 2005; 79: 2689-2699
Google Scholar - 41. Śliwa J., Niedźwiedzka P., Tokarz-Deptuła B., Deptuła W.: ReceptoryTLR w zarażeniach pierwotniakami. Medycyna Wet., 2008; 64: 1098-1103
Google Scholar - 42. Śliwa-Dominiak J., Deptuła W.: Characteristics of TIM and TAM receptors.Adv. Agr. Sci., 2010; 13: 89-95
Google Scholar - 43. Śliwa-Dominiak J., Deptuła W.: Mało znane receptory komórek odpornościowych– wybrane dane. Alergia Astma Immunol., 2010; 15:125-131
Google Scholar - 44. Tal M.C., Sasai M., Lee H.K., Yordy B., Shadel G.S., Iwasaki A.: Absenceof autophagy results in reactive oxygen species-dependent amplificationof RLR signaling. Proc. Natl. Acad. Sci. USA, 2009; 106: 2770-2775
Google Scholar - 45. Tokarz-Deptuła B., Niedźwiedzka P., Deptuła W.: Receptory Toll–podobne – nowe znaczniki w immunologii. Alergia Astma Immunol.,2006; 11: 23-28
Google Scholar - 46. Uchil P.D., Quinlan B.D., Chan W.T., Luna J.M., Mothes W.: TRIM E3ligases interfere with early and late stages of the retroviral life cycle.PLoS Pathog., 2008; 4: e16
Google Scholar - 47. Vieira P., de Waal-Malefyt R., Dang M.N., Johnson K.E., KasteleinR., Fiorentino D.F., deVries J.E., Roncarolo M.G., Mosmann T.R., MooreK.W.: Isolation and expression of human cytokine synthesis inhibitoryfactor cDNA clones: homology to Epstein-Barr virus open reading frameBCRFI. Proc. Natl. Acad. Sci. USA, 1991; 88: 1172-1176
Google Scholar - 48. Yan N., Chen Z.J.: Intrinsic antiviral immunity. Nat. Immunol., 2012;13: 214-222
Google Scholar