Krzysztof Dołowy , Piotr Bednarczyk , Renata Hordejuk , Beata Dworakowska , Ewa Nurowska , Wanda Jarzabek
Opublikowany: 2002-05-15
GICID: 01.3001.0000.3500
Dostępne wersje językowe: en
Wydanie: Postepy Hig Med Dosw 2002; 56 (3)
Abstrakt
There are 9 channels of the ClC family in mammals and few others in fishes, plants, yeast and bacteria. The ClC channels are present in different tissues and play a role in transmembrane potential stabilization, transepithelial transport, cell volume regulation, acidification of intracellular organelles. The genetic defects of ClC-1 chloride channel lead to myotonias, the defect in ClC-5 channel to the formation of stones in kidney, while the defect in ClC-Kb channel leads to the Bartter’s syndrome.