Abstrakt

Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders whose major hallmark is insulin resistance. Impaired mitochondrial activity, such as reduced ratio of energy production to respiration, has been implicated in the development of insulin resistance. Uncoupling proteins (UCPs) are proton carriers, expressed in the mitochondrial inner membrane, that uncouple oxygen consumption by the respiratory chain from ATP synthesis.

Przypisy

• 1. Adams A.E., Carroll A.M., Fallon P.G., Porter R.K.: Mitochondrial uncoupling protein 1 expression in thymocytes. Biochim. Biophys. Acta, 2008; 1777: 772-776
  Google Scholar
• 2. Brand M.D., Affourtit C., Esteves T.C., Green K., Lambert A.J., Miwa S., Pakay J.L., Parker N.: Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic. Biol. Med.; 2004; 37: 755-767
  Google Scholar
• 3. Brondani L.A., Assmann T.S., Duarte G.C., Gross J.L., Canani L.H., Crispim D.: The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus. Arq Bras. Endocrinol. Metabol., 2012; 56: 215-225
  Google Scholar
• 4. Carroll A.M., Haines L.R., Pearson T.W., Fallon P.G., Walsh C.M., Brennan C.M., Breen E.P., Porter R.K.: Identification of a functioning mitochondrial uncoupling protein 1 in thymus. J. Biol. Chem., 2005; 280: 15534-15543
  Google Scholar
• 5. Cheng Z., Almeida F.A.: Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link. Cell Cycle, 2014; 13: 890-897
  Google Scholar
• 6. De Loera-Rodriguez C.O., Delgado-Rizo V., Alvarado-Navarro A., Agraz-Cibrian J.M., Segura-Ortega J.E., Fafutis-Morris M.: Over- -expression of TLR4-CD14, pro-inflammatory cytokines, metabolic markers and NEFAs in obese non-diabetic Mexicans. J. Inflamm., 2014; 11: 39
  Google Scholar
• 7. Diano S., Horvath T.L.: Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. Trends Mol. Med., 2012; 18: 52-58
  Google Scholar
• 8. Echtay K.S., Roussel D., St-Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., Harper J.A., Roebuck S.J., Morrison A., Pickering S., Clapham J.C., Brand M.D.: Superoxide activates mitochondrial uncoupling proteins. Nature, 2002; 415: 96-99
  Google Scholar
• 9. Eckel R.H., Kahn S.E., Ferrannini E., Goldfine A.B., Nathan D.M., Schwartz M.W., Smith R.J., Smith S.R.: Obesity and type 2 diabetes: what can be unified and what needs to be individualized? J. Clin. Endocrinol. Metab., 2001; 96: 1654-1663
  Google Scholar
• 10. Emre Y., Nübel T.: Uncoupling protein UCP2: when mitochondrial activity meets immunity. FEBS Lett., 2010; 584: 1437-1442
  Google Scholar
• 11. Esser N., Legrand-Poels S., Piette J., Scheen A.J., Paquot N.: Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res. Clin. Pract., 2014; 105: 141-150
  Google Scholar
• 12. Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Levi-Meyrueis C., Bouillaud F., Seldin M.F., Surwit R.S., Ricquier D., Warden C.H.: Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet., 1997; 15: 269-272
  Google Scholar
• 13. Golbidi S., Badran M., Laher I.: Antioxidant and anti-inflammatory effects of exercise in diabetic patients. Exp. Diabetes Res., 2012; 2012: 941868
  Google Scholar
• 14. Hatanaka E., Monteagudo P.T., Marrocos M.S., Campa A.: Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes. Clin. Exp. Immunol., 2006; 146: 443-447
  Google Scholar
• 15. Højlund K., Mogensen M., Sahlin K., Beck-Nielsen H.: Mitochondrial dysfunction in type 2 diabetes and obesity. Endocrinol. Metab Clin. North Am., 2008; 37: 713-731
  Google Scholar
• 16. Krauss S., Zhang C.Y., Lowell B.B.: The mitochondrial uncoupling-protein homologues. Nat. Rev. Mol. Cell Biol., 2005; 6: 248-261
  Google Scholar
• 17. Lean M.E., James W.P., Jennings G., Trayhurn P.: Brown adipose tissue uncoupling protein content in human infants, children and adults. Clin. Sci., 1986; 71: 291-297
  Google Scholar
• 18. Liu J., Li J., Li W.J., Wang C.M.: The role of uncoupling proteins in diabetes mellitus. J. Diabetes Res., 2013; 2013: 585897
  Google Scholar
• 19. Mahadik S.R., Lele R.D., Saranath D., Seth A., Parikh V.: Uncoupling protein-2 (UCP2) gene expression in subcutaneous and omental adipose tissue of Asian Indians: Relationship to adiponectin and parameters of metabolic syndrome. Adipocyte, 2012; 1: 101-107
  Google Scholar
• 20. Maiese K., Morhan S.D., Chong Z.Z.: Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr. Neurovasc. Res., 2007; 4: 63-71
  Google Scholar
• 21. Mailloux R.J., Harper M.E.: Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radic. Biol. Med., 2011; 51: 1106-1115
  Google Scholar
• 22. Manoel-Caetano F.S., Xavier D.J., Evangelista A.F., Takahashi P., Collares C.V., Puthier D., Foss-Freitas M.C., Foss M.C., Donadi E.A., Passos G.A., Sakamoto-Hojo E.T.: Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease. Gene, 2012; 511: 151-160
  Google Scholar
• 23. Mohan V., Deepa R., Velmurugan K., Premalatha G.: Association of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6). Diabet. Med., 2005; 22: 863-870
  Google Scholar
• 24. Mori S., Yoshizuka N., Takizawa M., Takema Y., Murase T., Tokimitsu I., Saito M.: Expression of uncoupling proteins in human skin and skin-derived cells. J. Invest. Dermatol., 2008; 128: 1894-1900
  Google Scholar
• 25. Nordfors L., Hoffstedt J., Nyberg B., Thörne A., Arner P., Schalling M., Lönnqvist F.: Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects. Diabetologia, 1998; 41: 935-939
  Google Scholar
• 26. Pedersen S.B., Nyholm B., Kristensen K., Nielsen M.F., Schmitz O., Richelsen B.: Increased adiposity and reduced adipose tissue mRNA expression of uncoupling protein-2 in first-degree relatives of type 2 diabetic patients: evidence for insulin stimulation of UCP-2 and UCP-3 gene expression in adipose tissue. Diabetes Obes. Metab., 2005; 7: 98-105
  Google Scholar
• 27. Ritov V.B., Menshikova E.V., He J., Ferrell R.E., Goodpaster B.H., Kelley D.E.: Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes, 2005; 54: 8-14
  Google Scholar
• 28. Rousset S., Alves-Guerra M.C., Mozo J., Miroux B., Cassard-Doulcier A.M., Bouillaud F., Ricquier D.: The biology of mitochondrial uncoupling proteins. Diabetes, 2004; 53: S130-S135
  Google Scholar
• 29. Rupprecht A., Bräuer A.U., Smorodchenko A., Goyn J., Hilse K.E., Shabalina I.G., Infante-Duarte C., Pohl E.E.: Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation. PLoS One, 2012; 7: e41406
  Google Scholar
• 30. Saleh M.C., Wheeler M.B., Chan C.B.: Uncoupling protein-2: evidence for its function as a metabolic regulator. Diabetologia, 2002; 45: 174-187
  Google Scholar
• 31. van den Berg S.M., van Dam A.D., Rensen P.C., de Winther M.P., Lutgens E.: Immune modulation of brown(ing) adipose tissue in obesity. Endocr. Rev., 2017; 38: 46-68
  Google Scholar
• 32. Zhang C.Y., Baffy G., Perret P., Krauss S., Peroni O., Grujic D., Hagen T., Vidal-Puig A.J., Boss O., Kim Y.B., Zheng X.X., Wheeler M.B., Shulman G.I., Chan C.B., Lowell B.B.: Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, βcell dysfunction, and type 2 diabetes. Cell, 2001; 105: 745-755
  Google Scholar

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