Abstrakt

Introduction: The purpose of the study conducted on cystic fibrosis (CF) patients was the bacterial plaque accumulation and the gingival condition assessment, and microbial analysis of the subgingival biofilm. Materials/Methods: The study included 22 CF adult patients and 22 healthy controls, sex and age compatible with the CF patients. The dental plaque was assessed using plaque index (PLI), and the gingival status using gingival index (GI). Analyses of the subgingival biofilm were performed by the real-time polymerase chain reaction (PCR) test. Results: The mean value of GI in CF patients was 0.39 ±0.36 and was significantly lower comparing to the healthy controls (1.02 ±0.63), PLI was similar in both the groups (1.31 ±0.69) for the study group and 1.04 ±0.62 for controls). In CF patients there was no correlation between PLI and GI, which was observed in the control group. In both the groups there was a correlation between PLI and the total number of periopathogens. Furthermore, in the control group, there was a correlation between GI and the number of periopathogens. Such a correlation was not observed in the CF patients. Conclusions: In patients with CF, the lack of correlation between the amount of tooth deposits and the gingival condition may indicate a stable, most likely pharmacologically conditioned oral biofilm ecology. Among the aetiological factors of gingivitis and periodontitis in patients with CF, the bacterial activity does not seem to be modified. However, the unsatisfactory oral hygiene found in the study participants does not exclude the possibility of disease development in the future.

Przypisy

• 1. Aps J.K., Van Maele G.O., Martens L.C.: Caries experience andoral cleanliness in cystic fibrosis homozygotes and heterozygotes.Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2002; 93:560–563
  Google Scholar
• 2. Dabrowska E., Bahuszewska K., Minarowska A., Kaczmarski M.,Niedźwiecka-Andrzejewicz I., Stokowska W.: Assessment of dentalstatus and oral hygiene in the study population of cystic fibrosispatients in the Podlasie province. Adv. Med. Sci., 2006; 51: 100–103
  Google Scholar
• 3. Ferrazzano G.F., Orlando S., Sangianantoni G., Cantile T., IngenitoA.: Dental and periodontal health status in children affected by cystic fibrosis in a southern Italian region. Eur. J. Paediatr.Dent., 2009; 10: 65–68
  Google Scholar
• 4. Haffajee A.D., Socransky S.S., Patel M.R., Song X.: Microbialcomplexes in supragingival plaque. Oral Microbiol. Immunol., 2008; 23: 196–205
  Google Scholar
• 5. Huang R., Li M., Gregory R.L.: Bacterial interactions in dentalbiofilm. Virulence, 2011; 2: 435–444
  Google Scholar
• 6. Lang N.P., Bartold P.M.: Periodontal health. J. Periodontol., 2018; 89: S9–S16
  Google Scholar
• 7. Larsen T., Fiehn N.E.: Dental biofilm infections – an update.APMIS, 2017; 125: 376–384
  Google Scholar
• 8. Löe H.: The Gingival Index, the Plaque Index and the RetentionIndex Systems. J. Periodontol., 1967; 38: 610–616
  Google Scholar
• 9. Macovei L., McCafferty J., Chen T., Teles F., Hasturk H., PasterB.J., Campos-Neto A.: The hidden ‘mycobacteriome’ of the humanhealthy oral cavity and upper respiratory tract. J. Oral Microbiol.,2015; 7: 26094
  Google Scholar
• 10. Marsh P.D.: Dental plaque: Biological significance of a biofilmand community life-style. J. Clin. Periodontol., 2005; 32: 7–15
  Google Scholar
• 11. Martens L.C., Aps J.K.M., Van Maele G.O.: Is oral health at riskin people with cystic fibrosis? Eur. J. Paediatr. Dent. 2001; 2: 21–27
  Google Scholar
• 12. Murakami S., Mealey B.L., Mariotti A., Chapple I.L.: Dentalplaque-induced gingival conditions. J. Periodontol. 2018; 89: S17–S27
  Google Scholar
• 13. Narang A., Maguire A., Nunn J.H., Bush A.: Oral health andrelated factors in cystic fibrosis and other chronic respiratorydisorders. Arch. Dis. Child., 2003; 88: 702–707
  Google Scholar
• 14. Pawlaczyk-Kamieńska T., Borysewicz-Lewicka M., Batura-GabryelH.: Salivary biomarkers and oral microbial load in relationto the dental status of adults with cystic fibrosis. Mmicroorganisms,2019; 7: 692
  Google Scholar
• 15. Pawlaczyk-Kamieńska T., Borysewicz-Lewicka M., Śniatała R.:Periodontal condition and periodontal risk assessment in adultpatients with cystic fibrosis. Ann. Agric. Environ. Med., 2020; 27:235–239
  Google Scholar
• 16. Pawlaczyk-Kamieńska T., Borysewicz-Lewicka M., ŚniatałaR., Batura-Gabryel H., Cofta S.: Dental and periodontal manifestationsin patients with cystic fibrosis – a systematic review. J. Cyst.Fibros. 2019; 18: 762–771
  Google Scholar
• 17. Peker S., Kargul B., Tanboga I., Tunali-Akbay T., Yarat A., KarakocF., Ersu R., Dagli E.: Oral health and related factors in a groupof children with cystic fibrosis in Istanbul, Turkey. Niger. J. Clin.Pract., 2015; 18: 56–60
  Google Scholar
• 18. ] Sanz M., Beighton D., Curtis M.A., Cury J.A., Dige I., DommischH., Ellwood R., Giacaman R.A., Herrera D., Herzberg M.C.,Könönen E., Marsh P.D., Meyle J., Mira A., Molina A. et al.: Role ofmicrobial biofilms in the maintenance of oral health and in thedevelopment of dental caries and periodontal diseases. Consensusreport of group 1 of the Joint EFP/ORCA workshop on the boundariesbetween caries and periodontal disease. J. Clin. Periodontol.,2017; 44: S5–S11
  Google Scholar
• 19. Scannapieco F.A.: The oral microbiome: Its role in health and inoral and systemic infections. Clin. Microbiol. News., 2013; 35: 163–139
  Google Scholar
• 20. Silness J., Löe H.: Periodontal disease in pregnancy. II. Correlationbetween oral hygiene and periodontal condition. ActaOdontol. Scand., 1964; 22: 121–135
  Google Scholar
• 21. Socransky S.S., Haffajee A.D., Cugini M.A., Smith C., Kent R.L.Jr.:Microbial complexes in subgingival plaque. J. Clin. Periodontol.,1998; 25: 134–144
  Google Scholar
• 22. World Health Organization: Oral Health Surveys. Basic Methods,4th ed.; World Health Organization, Geneva 1997
  Google Scholar

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