Maria Warwas
Opublikowany: 2003-11-15
GICID: 01.3001.0000.3565
Dostępne wersje językowe: en
Wydanie: Postepy Hig Med Dosw 2003; 57 (6)
Abstrakt
Cathepsin B (CB) is a tumour-associated cysteine peptidase, which plays an important role in the proteolytic cascade involved in cancer invasion. Therefore, pro-drugs specifically activated by CB are expected to possess enhanced tumour selected properties. This paper presents the actual stage of knowledge on anticancer therapy strategies using CB as a side-specific activator of immuno- or polymer-conjugates (Antibody Directed Enzyme Pro-Drug Therapy or Polymer Directed Enzyme Pro-Drug Therapy, respectively). Usefulness of CB determinations in the laboratory diagnosis of neoplastic diseases is also presented.