Crystal structures of bacterial ion channels reveal molecular basis of ion selectivity

Piotr Koprowski Artur Furmanek Andrzej Kubalski

Opublikowany: 2002-05-15

GICID: 01.3001.0000.3496

Dostępne wersje językowe: en

Wydanie: Postepy Hig Med Dosw 2002; 56 (3)

Abstrakt

The principles of ionic selectivity of the two crystallised bacterial ion channels are described. These channels are: the potassium channel KcsA, whose amino-acid sequence is homologous to the eukaryotic voltage–dependent potassium channels and the chloride channel EcClC that is a prokaryotic member of the ClC family of chloride channels. In conclusion: although the overall molecular architecture of KcsA is different from that of EcClC, the selectivity filters in both cases show similarities. They both utilise helix dipoles organised within the channel molecule in such a fashion to produce electrostatically favourable environment for anions (in the case of EcClC) or cations (in the case of KcsA).

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