Waldemar Przybyszewski
Opublikowany: 2001-11-15
GICID: 01.3001.0000.3475
Dostępne wersje językowe: en
Wydanie: Postepy Hig Med Dosw 2001; 55 (6)
Abstrakt
This review reports the evidence for the participation of final products of lipid peroxidation in the anticancer mechanism of ionizing radiation and radiomimetic cytostatics. Processes of lipid peroxidation occur endogenously in response to oxidative stress and great diversity of reactive metabolites is formed. However, direct observation of radical reaction in pathophysiology of cells, tissues and organs is limited technically. Most investigations focused on the indirect assessement of their final products, aldehydes. The peroxidative breakdown of polyunsaturated fatty acids is belived to be involved in the regulation of cell division, and antitumor effect through biochemical and genetic processes.