Regulation of human T lymphocyte potassium channel function by intracellular second messengers – role of calcium, cyclic AMP and membrane lipid metabolities

Andrzej Teisseyre

Opublikowany: 2000-05-15

GICID: 01.3001.0000.3285

Dostępne wersje językowe: en

Wydanie: Postepy Hig Med Dosw 2000; 54 (3)

Abstrakt

This review focuses on the influence of well-known intracellular second messengers on the activity of potassium channels expressed in human T lymphocytes. Basic biophysical properties of the channels are briefly presented. Available data on the regulatory role of intracellular calcium and cyclic AMP is reviewed. Finally, a possible influence of lipid compounds, especially high-density lipoproteins, lysophospholipids and sphingolipids, on the expression and activity of potassium channels in human T lymphocytes is discussed

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