Abstrakt

Rytm theta jest jednym z najlepiej zsynchronizowanych wzorców aktywności oscylacyjnej rejestrowanych w mózgach ssaków. U ludzi, rytm ten obserwowany jest podczas snu REM, nawigacji przestrzennej, procesów pamięciowych, analitycznych oraz językowych. Może być również traktowany jako nieswoisty marker stanów patologicznych ośrodkowego układu nerwowego, takich jak choroba Alzheimera czy padaczka. Główną strukturą zaangażowaną w generowanie wzorca aktywności bioelektrycznej, zarówno u ludzi, jak i u gryzoni (najczęściej badanych zwierząt laboratoryjnych), jest formacja hipokampa. Jej funkcjonowanie zależy od współdziałania wielu innych struktur układu nerwowego. Jedną z nich jest obszar tylnego podwzgórza, który jest istotnym elementem układów neuronalnych modulujących zdolność formacji hipokampa do generowania rytmu theta. Przedstawione w artykule wyniki badań podkreślają rolę obszaru tylnego podwzgórza, jako modulatora hipokampalnego rytmu theta, ale wykazują również, że obszar ten jest zdolny do samodzielnego, niezależnego od wpływu innych struktur, generowania rytmicznej aktywności theta.

Przypisy

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